U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HP4 Heterochromatin protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38887, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HP4provided by FlyBase
    Official Full Name
    Heterochromatin protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0035829
    Locus tag
    Dmel_CG8044
    See related
    AllianceGenome:FB:FBgn0035829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM01628; CG8044; Dmel\CG8044; hip; Hip
    Summary
    Involved in chromatin organization. Located in chromocenter; chromosome; and nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HP4 in Genome Data Viewer
    Location:
    66A21-66A21; 3-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7975438..7976154, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7968538..7969254, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease X25 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene nemo Neighboring gene transfer RNA:Alanine-AGC 2-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162556, Free PMC Article
    2. Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP. Joppich C, et al. Chromosome Res, 2009. PMID 19190990, Free PMC Article
    3. The winged-helix transcription factor JUMU regulates development, nucleolus morphology and function, and chromatin organization of Drosophila melanogaster. Hofmann A, et al. Chromosome Res, 2010 Apr. PMID 20213139
    4. Phase separation drives heterochromatin domain formation. Strom AR, et al. Nature, 2017 Jul 13. PMID 28636597, Free PMC Article
    5. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. McLellan JS, et al. Nature, 2008 Oct 16. PMID 18794898, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hip interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila
      Title: Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    heterochromatin protein 4
    Names
    CG8044-PA
    CG8044-PB
    HP1-interacting protein
    HP4-PA
    HP4-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7975438..7976154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139909.3 → NP_648166.2  heterochromatin protein 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648166.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NR9, Q8IQ92
      Related
      FBpp0076479

    2. NM_168247.3 → NP_729314.1  heterochromatin protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3N9, Q9VSC4
      Related
      FBpp0076480
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQ92 Q8IQ92
    Q8T3N9 Q8T3N9
    Q9VSC4 Q9VSC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools