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    CG46385 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG46385provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286778
    Locus tag
    Dmel_CG46385
    See related
    AllianceGenome:FB:FBgn0286778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.176; BEST:LD33067; CG1383; CG1557; CG30497; CG30947; CG45093; Dmel\CG46385; EP(2)2618; NEST:bs36c04
    Old locus tag
    Dmel_CG30497; Dmel_CG45093
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization. Located in cytosol and nucleoplasm. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; embryonic/larval garland cell; epithelium; and somatic precursor cell. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. Orthologous to several human genes including TENT5A (terminal nucleotidyltransferase 5A); TENT5B (terminal nucleotidyltransferase 5B); and TENT5C (terminal nucleotidyltransferase 5C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG46385 in Genome Data Viewer
    Location:
    43E13-43E16; 2-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7737019..7782637, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3624524..3670142, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gdap2 Neighboring gene antisense RNA:CR45108 Neighboring gene mir-4980 stem loop Neighboring gene cinnabar Neighboring gene Calcineurin B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster. Watanabe Y, et al. Genetics, 2009 Mar. PMID 19114461, Free PMC Article
    2. A screen for genes that function in leg disc regeneration in Drosophila melanogaster. McClure KD, et al. Mech Dev, 2008 Jan-Feb. PMID 18036784, Free PMC Article
    3. Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. Maruyama R, et al. PLoS One, 2011. PMID 21698206, Free PMC Article
    4. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
    5. The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila. Rollmann SM, et al. Genetics, 2007 Jun. PMID 17435226, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c7779880-7779465 mobile_element_type = transposon:HMS-Beagle{}3102

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG46385-PA
    CG46385-PB
    CG46385-PC
    CG46385-PD
    CG46385-PE
    CG46385-PF
    NP_001260791.1
    NP_001356959.1
    NP_001356960.1
    NP_610321.2
    NP_724600.1
    NP_724601.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7737019..7782637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273862.1 → NP_001260791.1  uncharacterized protein Dmel_CG46385, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z745
      Conserved Domains (1) summary
      pfam07984
      Location:52 → 379
      NTP_transf_7; Nucleotidyltransferase

    2. NM_001370032.1 → NP_001356960.1  uncharacterized protein Dmel_CG46385, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P7V9T9
      Conserved Domains (1) summary
      pfam07984
      Location:83 → 410
      NTP_transf_7; Nucleotidyltransferase

    3. NM_165555.3 → NP_724600.1  uncharacterized protein Dmel_CG46385, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXN9, Q9V4R7
      Related
      FBpp0423178
      Conserved Domains (1) summary
      pfam07984
      Location:83 → 410
      NTP_transf_7; Nucleotidyltransferase

    4. NM_001370031.1 → NP_001356959.1  uncharacterized protein Dmel_CG46385, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P7VA97
      Conserved Domains (1) summary
      pfam07984
      Location:400 → 727
      NTP_transf_7; Nucleotidyltransferase

    5. NM_136477.4 → NP_610321.2  uncharacterized protein Dmel_CG46385, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610321.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z743, Q6AWD9
      Related
      FBpp0423177
      Conserved Domains (1) summary
      pfam07984
      Location:400 → 727
      NTP_transf_7; Nucleotidyltransferase

    6. NM_165556.3 → NP_724601.1  uncharacterized protein Dmel_CG46385, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z745
      Related
      FBpp0423180
      Conserved Domains (1) summary
      pfam07984
      Location:52 → 379
      NTP_transf_7; Nucleotidyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4P7V9T9 A0A4P7V9T9
    A0A4P7VA97 A0A4P7VA97
    A1Z743 A1Z743
    A1Z745 A1Z745
    Q8SXN9 Q8SXN9

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