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    Fit2 Fermitin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fit2provided by FlyBase
    Official Full Name
    Fermitin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036688
    Locus tag
    Dmel_CG7729
    See related
    AllianceGenome:FB:FBgn0036688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg7729; CG7729; Dmel\CG7729; Fit 2; fit2
    Summary
    Predicted to enable integrin binding activity. Involved in cardiac muscle tissue development. Predicted to be active in cell-substrate junction. Human ortholog(s) of this gene implicated in Kindler syndrome; leukocyte adhesion deficiency 1; leukocyte adhesion deficiency 3; telangiectasis; and vesiculobullous skin disease. Orthologous to several human genes including FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fit2 in Genome Data Viewer
    Location:
    73E4-73E4; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17024328..17027117)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17017428..17020217)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antennal protein 10 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 8 Neighboring gene long non-coding RNA:CR45756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. Catterson JH, et al. PLoS One, 2013. PMID 23690969, Free PMC Article
    2. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Shulman JM, et al. Hum Mol Genet, 2014 Feb 15. PMID 24067533, Free PMC Article
    3. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models. Giong HK, et al. Int J Mol Sci, 2021 Aug 6. PMID 34445171, Free PMC Article
    4. An alternative mode of epithelial polarity in the Drosophila midgut. Chen J, et al. PLoS Biol, 2018 Oct. PMID 30339698, Free PMC Article
    5. De novo apical domain formation inside the Drosophila adult midgut epithelium. Chen J, et al. Elife, 2022 Sep 28. PMID 36169289, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-substrate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fermitin 2
    Names
    CG7729-PA
    Fermitin2
    Fit2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17024328..17027117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140690.3 → NP_648947.1  fermitin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVD2
      Related
      FBpp0075035
      Conserved Domains (5) summary
      smart00295
      Location:259 → 351
      B41; Band 4.1 homologues
      cd01237
      Location:408 → 536
      PH_fermitin; Fermitin family pleckstrin homology (PH) domain
      cd13205
      Location:603 → 693
      FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
      pfam00169
      Location:408 → 515
      PH; PH domain
      pfam00373
      Location:310 → 365
      FERM_M; FERM central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVD2 Q9VVD2

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