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    Karl karl [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Karlprovided by FlyBase
    Official Full Name
    karlprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030334
    Locus tag
    Dmel_CG4139
    See related
    AllianceGenome:FB:FBgn0030334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4139; Dmel\CG4139; karl
    Summary
    Predicted to be involved in lipid metabolic process and response to reactive oxygen species. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Karl in Genome Data Viewer
    Location:
    10E3-10E3; 1-36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11787381..11792253)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11681414..11686286)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene miniature Neighboring gene uncharacterized protein Neighboring gene dusky Neighboring gene antisense RNA:CR44962 Neighboring gene Casein kinase II beta subunit Neighboring gene Heat shock protein 70 cognate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta-subunit. Jauch E, et al. Gene, 2002 Sep 18. PMID 12406573
    2. The Drosophila melanogaster DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms. Jauch E, et al. Gene, 2006 Jun 7. PMID 16530986
    3. Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. Hull-Thompson J, et al. PLoS Genet, 2009 Apr. PMID 19390610, Free PMC Article
    4. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Zhang D, et al. Chromosoma, 2011 Feb. PMID 20857302
    5. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. Ruiz M, et al. FASEB J, 2014 Apr. PMID 24361577

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to reactive oxygen species IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    karl
    Names
    CG4139-PA
    CG4139-PB
    CG4139-PC
    CG4139-PD
    Karl-PA
    Karl-PB
    Karl-PC
    Karl-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11787381..11792253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298208.1 → NP_001285137.1  karl, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R53, Q9VYU5

    2. NM_001298209.1 → NP_001285138.1  karl, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R53, Q9VYU5

    3. NM_132520.4 → NP_572748.2  karl, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572748.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R53, Q9VYU5
      Related
      FBpp0073402

    4. NM_167303.3 → NP_727559.1  karl, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R53, Q9VYU5
      Related
      FBpp0073401
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R53 Q95R53
    Q962B6 Q962B6
    Q9VYU5 Q9VYU5

    Gene LinkOut

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