Rab39 Rab39 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab39provided by FlyBase
Official Full Name: Rab39provided by FlyBase
Primary source: FLYBASE:FBgn0029959
Locus tag: Dmel_CG12156
See related: AllianceGenome:FB:FBgn0029959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24640395; AAF46271; CG12156; Dmel\CG12156; DmRab39; rab39
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of autophagosome maturation and secretion of lysosomal enzymes. Located in several cellular components, including Golgi apparatus; autolysosome membrane; and neuronal cell body. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Waisman syndrome and non-syndromic X-linked intellectual disability 72. Orthologous to human RAB39A (RAB39A, member RAS oncogene family) and RAB39B (RAB39B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7734923..7736756)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7628956..7630789)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila Rab39 Attenuates Lysosomal Degradation.
Title: Drosophila Rab39 Attenuates Lysosomal Degradation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretion of lysosomal enzymes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in autolysosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	HDA more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info