Spc105R Spc105-related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Spc105Rprovided by FlyBase
Official Full Name: Spc105-relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0037025
Locus tag: Dmel_CG11451
See related: AllianceGenome:FB:FBgn0037025
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11451; Dmel\CG11451; dmKNL-1; DmSpc105; dmSpc105R; KNL1; Spc105; Spc105-R; spc105r; spc105R; Spc105r
Summary: Involved in attachment of spindle microtubules to kinetochore and kinetochore assembly. Part of outer kinetochore. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and neuroblasts. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77E6-77E8; 3-47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20800410..20806853)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20793510..20799953)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes.
Title: Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes.
The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction.
Title: The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction.
Two mechanisms have been proposed to maintain co-orientation in Drosophila oocytes: one involves SPC105R to protect cohesins at sister centromeres, and another involves PP1-87B to regulate spindle forces at end-on attachments.
Title: Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.
kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E motor.
Title: Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.
Genetic characterization of Drosophila Spc105 shows that a truncated version lacking the rapidly evolving, repetitive central third still provides all essential functions.
Title: Intrakinetochore localization and essential functional domains of Drosophila Spc105.
Drosophila Spc105R, a protein very much diverged from its counterparts in other species, might not only be playing the role of Spc105 itself but also of Dsn1
Title: Searching for Drosophila Dsn1 kinetochore protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0981 (e-PCR)
- UniSTS:35019

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed