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    CG5065 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5065provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034145
    Locus tag
    Dmel_CG5065
    See related
    AllianceGenome:FB:FBgn0034145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5065; FAR1; FAR1/2
    Summary
    Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in ether lipid biosynthetic process; long-chain fatty-acyl-CoA metabolic process; and wax biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Is expressed in adult head; embryonic/larval foregut; embryonic/larval hindgut; and larval central nervous system. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to several human genes including FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5065 in Genome Data Viewer
    Location:
    53C11-53C12; 2-80 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16607654..16624894)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12495159..12512399)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Anaplastic lymphoma kinase Neighboring gene gprs Neighboring gene Amylase related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
    2. The Zic family homologue Odd-paired regulates Alk expression in Drosophila. Mendoza-García P, et al. PLoS Genet, 2017 Apr. PMID 28369060, Free PMC Article
    3. Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. Lorén CE, et al. Genes Cells, 2001 Jun. PMID 11442633, Free PMC Article
    4. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
    5. Gene expression and morphogenesis during the deposition of Drosophila wing cuticle. Adler PN. Fly (Austin), 2017 Jul 3. PMID 28631994, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wax biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisomal membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5065-PA
    CG5065-PB
    CG5065-PC
    CG5065-PD
    CG5065-PE
    fatty acyl-CoA reductase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16607654..16624894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137299.4 → NP_611143.1  uncharacterized protein Dmel_CG5065, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAI5
      UniProtKB/TrEMBL
      E1JH83
      Related
      FBpp0086254
      Conserved Domains (2) summary
      cd05236
      Location:126 → 445
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:472 → 562
      Sterile; Male sterility protein

    2. NM_001259441.2 → NP_001246370.1  uncharacterized protein Dmel_CG5065, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAI5
      UniProtKB/TrEMBL
      E1JH83
      Conserved Domains (2) summary
      cd05236
      Location:126 → 445
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:472 → 562
      Sterile; Male sterility protein

    3. NM_001259442.2 → NP_001246371.1  uncharacterized protein Dmel_CG5065, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246371.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAI5
      UniProtKB/TrEMBL
      E1JH83
      Conserved Domains (2) summary
      cd05236
      Location:126 → 445
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:472 → 562
      Sterile; Male sterility protein

    4. NM_001169698.3 → NP_001163169.1  uncharacterized protein Dmel_CG5065, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163169.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAI5
      UniProtKB/TrEMBL
      E1JH83
      Conserved Domains (2) summary
      cd05236
      Location:126 → 445
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:472 → 562
      Sterile; Male sterility protein

    5. NM_001169697.3 → NP_001163168.1  uncharacterized protein Dmel_CG5065, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAI5
      UniProtKB/TrEMBL
      E1JH83
      Conserved Domains (2) summary
      cd05236
      Location:126 → 445
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:472 → 562
      Sterile; Male sterility protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAI5.1 A1ZAI5
    E1JH83 E1JH83

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