Polr2C RNA polymerase II subunit C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Polr2Cprovided by FlyBase
Official Full Name: RNA polymerase II subunit Cprovided by FlyBase
Primary source: FLYBASE:FBgn0026373
Locus tag: Dmel_CG7885
See related: AllianceGenome:FB:FBgn0026373
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 152117_at; BG:DS00941.10; br17; CG7885; D-rpII33; Dmel\CG7885; l(2)34Dg; l(2)br17; l(2)k05605; l34Dg; pol II; Pol II; Pol II RPII33; polII; PolII; PolIIo; Rbp3; RNA pol II; RNA Pol II; RNA polII; RNAP; rpb3; Rpb3; RPB3; rpII33; RpII33; Rpll33
Summary: Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase II activity. Involved in cellular response to heat. Located in cytoplasm; nucleus; and polytene chromosome puff. Part of RNA polymerase II, core complex. Is expressed in adult head and organism. Orthologous to human POLR2C (RNA polymerase II subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13833337..13834306)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13833337..13834306)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA-directed 5'-3' RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
contributes_to RNA polymerase II activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II, core complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II, core complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

Names: CG7885-PA; Polr2C-PA; RNA polymerase II; RNA polymerase II 33kD subunit; RNA polymerase II subunit 3; lethal 17 in the black-reduced region; lethal(2)34Dg

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