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    Cks30A Cyclin-dependent kinase subunit 30A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cks30Aprovided by FlyBase
    Official Full Name
    Cyclin-dependent kinase subunit 30Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010314
    Locus tag
    Dmel_CG3738
    See related
    AllianceGenome:FB:FBgn0010314
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdi2; Cdi2; CDI2; CG3738; cks; Cks; cks30A; DmCks1; Dmel\CG3738; fs(2)rem; rem; U40077
    Summary
    Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Involved in several processes, including anaphase-promoting complex-dependent catabolic process; spindle assembly involved in female meiosis I; and syncytial blastoderm mitotic cell cycle. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Orthologous to several human genes including CKS1B (CDC28 protein kinase regulatory subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cks30A in Genome Data Viewer
    Location:
    30A8-30A8; 2-35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9330763..9331981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9330763..9331981)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45457 Neighboring gene uncharacterized protein Neighboring gene Excitatory amino acid transporter 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Swan A, et al. Cell Cycle, 2005 Oct. PMID 16138012
    2. A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis. Pearson NJ, et al. EMBO Rep, 2005 Nov. PMID 16170306, Free PMC Article
    3. Cks85A and Skp2 interact to maintain diploidy and promote growth in Drosophila. Ghorbani M, et al. Dev Biol, 2011 Oct 1. PMID 21827746
    4. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Swan A, et al. Development, 2007 Mar. PMID 17251266, Free PMC Article
    5. Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Finley RL Jr, et al. Proc Natl Acad Sci U S A, 1994 Dec 20. PMID 7809159, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in histoblast morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase subunit 30A
    Names
    CG3738-PA
    Cks30A-PA
    Cyclin-dependent kinase interactor 2
    remnants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9330763..9331981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057599.4 → NP_476947.1  Cyclin-dependent kinase subunit 30A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24152, Q9VLD0
      UniProtKB/TrEMBL
      A0A1B2AK90
      Related
      FBpp0079399
      Conserved Domains (1) summary
      pfam01111
      Location:7 → 72
      CKS; Cyclin-dependent kinase regulatory subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24152.1 Q24152

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