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    CG6178 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6178provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039156
    Locus tag
    Dmel_CG6178
    See related
    AllianceGenome:FB:FBgn0039156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6178; FACL
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in several structures, including adult head; adult heart; epithelium; ganglia; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6178 in Genome Data Viewer
    Location:
    95E5-95E6; 3-83 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24152347..24154896)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19978069..19980618)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase Neighboring gene Myosin 95E Neighboring gene TBC1 domain family member 7 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional conversion of fatty acyl-CoA synthetase to firefly luciferase by site-directed mutagenesis: a key substitution responsible for luminescence activity. Oba Y, et al. FEBS Lett, 2009 Jun 18. PMID 19450587
    2. Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins. Mofford DM, et al. ACS Chem Biol, 2017 Dec 15. PMID 29073357, Free PMC Article
    3. Catalytic properties of domain-exchanged chimeric proteins between firefly luciferase and Drosophila fatty Acyl-CoA synthetase CG6178. Oba Y, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090919
    4. Latent luciferase activity in the fruit fly revealed by a synthetic luciferin. Mofford DM, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616520, Free PMC Article
    5. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phylogenetic analysis indicated that firefly luciferase and CG6178 genes belong to the group of plant 4-coumarate
      Title: Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase.
    2. The enzymatic properties of CG6178 including substrate specificity, pH dependency and optimal temperature were close to those of firefly luciferase and rat fatty acyl-CoA synthetase.
      Title: Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CoA-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables luciferin monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty-acyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6178-PA
    fatty Acyl-CoA synthetase
    fatty acyl-CoA synthase
    NP_651221.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24152347..24154896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142964.3 → NP_651221.1  uncharacterized protein Dmel_CG6178 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCC6
      Related
      FBpp0083935
      Conserved Domains (2) summary
      cd05911
      Location:43 → 529
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      PLN02246
      Location:26 → 537
      PLN02246; 4-coumarate--CoA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCC6 Q9VCC6

    Gene LinkOut

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