U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cad86C Cadherin 86C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41302, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cad86Cprovided by FlyBase
    Official Full Name
    Cadherin 86Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261053
    Locus tag
    Dmel_CG42601
    See related
    AllianceGenome:FB:FBgn0261053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP07955; CG31393; CG31425; CG33112; CG42601; CG4509; CG4655; CT14654; CT15041; DCad86C; Dmel\CG42601
    Old locus tag
    Dmel_CG4509; Dmel_CG4655
    Summary
    Predicted to enable calcium ion binding activity. Involved in regulation of cell shape. Part of subapical complex. Is expressed in several structures, including eye disc morphogenetic furrow; eye disc posterior to the morphogenetic furrow; main body follicle cell; spermatozoon; and stigmatophore. Human ortholog(s) of this gene implicated in cone-rod dystrophy 15. Orthologous to human CDHR1 (cadherin related family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cad86C in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10827079..10849030)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6652801..6674752)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tubulin tyrosine ligase-like 15 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila. Pierini G, et al. Sci Rep, 2023 May 25. PMID 37231029, Free PMC Article
    2. Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. Schlichting K, et al. Mech Dev, 2008 Aug. PMID 18539010
    3. Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling. Richard M, et al. Dev Biol, 2015 Dec 1. PMID 26455410
    4. Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty. Glassford WJ, et al. Dev Cell, 2015 Sep 14. PMID 26343453, Free PMC Article
    5. Cadherins in embryonic and neural morphogenesis. Tepass U, et al. Nat Rev Mol Cell Biol, 2000 Nov. PMID 11253370

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of subapical complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cadherin 86C
    Names
    CG42601-PC
    CG42601-PD
    CG42601-PE
    CG42601-PF
    CG42601-PG
    Cad86C-PC
    Cad86C-PD
    Cad86C-PE
    Cad86C-PF
    Cad86C-PG
    cadherin Cad86C

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10827079..10849030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176458.4 → NP_788635.3  cadherin 86C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788635.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GN10, Q8MZ37, Q9VGW1
      UniProtKB/TrEMBL
      A0A0B4K655
      Conserved Domains (1) summary
      cd11304
      Location:605 → 703
      Cadherin_repeat; Cadherin tandem repeat domain

    2. NM_001260105.1 → NP_001247034.1  cadherin 86C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6P8
      Conserved Domains (1) summary
      cd11304
      Location:605 → 703
      Cadherin_repeat; Cadherin tandem repeat domain

    3. NM_001260104.1 → NP_001247033.1  cadherin 86C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GN10, Q8MZ37, Q9VGW1
      UniProtKB/TrEMBL
      A0A0B4K6E3
      Conserved Domains (1) summary
      cd11304
      Location:605 → 703
      Cadherin_repeat; Cadherin tandem repeat domain

    4. NM_001260102.1 → NP_001247031.1  cadherin 86C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GN10, Q8MZ37, Q9VGW1
      UniProtKB/TrEMBL
      A0A0B4K655
      Conserved Domains (1) summary
      cd11304
      Location:605 → 703
      Cadherin_repeat; Cadherin tandem repeat domain

    5. NM_001260103.1 → NP_001247032.1  cadherin 86C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GN10, Q8MZ37, Q9VGW1
      UniProtKB/TrEMBL
      A0A0B4K720
      Conserved Domains (2) summary
      cd11304
      Location:577 → 675
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:260 → 336
      CA; Cadherin repeats
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K655 A0A0B4K655
    A0A0B4K6E3 A0A0B4K6E3
    A0A0B4K6P8 A0A0B4K6P8
    A0A0B4K720 A0A0B4K720
    Q95SX1 Q95SX1
    Q9VGW1.3 Q9VGW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools