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    Phae1 Phaedra 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phae1provided by FlyBase
    Official Full Name
    Phaedra 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263234
    Locus tag
    Dmel_CG16996
    See related
    AllianceGenome:FB:FBgn0263234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16996; Dmel\CG16996; SP134
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phae1 in Genome Data Viewer
    Location:
    33C4-33C4; 2-46 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12109417..12110664)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12109417..12110664)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Threonyl-tRNA synthetase Neighboring gene Rab6 Neighboring gene Phaedra 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The developmental role of warthog, the notch modifier encoding Drab6. Purcell K, et al. J Cell Biol, 1999 Aug 23. PMID 10459009, Free PMC Article
    2. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article
    3. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
    4. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442, Free PMC Article
    5. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phaedra 1
    Names
    CG16996-PA
    CG16996-PB
    Phae1-PA
    Phae1-PB
    NP_001285870.1
    NP_609550.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12109417..12110664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298941.1 → NP_001285870.1  phaedra 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKA9
      Conserved Domains (2) summary
      smart00020
      Location:35 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:36 → 266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_135706.4 → NP_609550.1  phaedra 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKA9
      Related
      FBpp0079916
      Conserved Domains (2) summary
      smart00020
      Location:35 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:36 → 266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKA9 Q9VKA9

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