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    Rad17 Rad17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad17provided by FlyBase
    Official Full Name
    Rad17provided by FlyBase
    Primary source
    FLYBASE:FBgn0025808
    Locus tag
    Dmel_CG7825
    See related
    AllianceGenome:FB:FBgn0025808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7825; Dmel\CG7825; DmRad17/24
    Summary
    Predicted to enable chromatin binding activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in DNA damage checkpoint signaling; DNA repair; and mitotic DNA replication checkpoint signaling. Predicted to be part of Rad17 RFC-like complex. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rad17 in Genome Data Viewer
    Location:
    88C10-88C10; 3-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14661176..14663197, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10486898..10488919, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) L1231 Neighboring gene uncharacterized protein Neighboring gene Hexamethylene bisacetamide inducible Neighboring gene meltrin Neighboring gene Histone H1 variant BigH1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Krause SA, et al. Mol Cell Biol, 2001 Aug. PMID 11438670, Free PMC Article
    2. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. Dean FB, et al. Genomics, 1998 Dec 15. PMID 9878245
    3. Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway. Tsuchiya A, et al. FEBS J, 2007 Apr. PMID 17381512
    4. Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila. Güneş M, et al. Sci Total Environ, 2023 Dec 15. PMID 37633389
    5. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Li F, et al. Nat Commun, 2021 Jun 22. PMID 34158506, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad17 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rad17
    Names
    CG7825-PA
    Rad17-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14661176..14663197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142125.4 → NP_650382.3  Rad17 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650382.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96532, Q8SYV6
      Related
      FBpp0082433
      Conserved Domains (2) summary
      pfam03215
      Location:87 → 455
      Rad17; Rad17 cell cycle checkpoint protein
      pfam13238
      Location:131 → 165
      AAA_18; AAA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96532 O96532
    Q7KND1 Q7KND1
    Q8SYV6 Q8SYV6

    Gene LinkOut

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