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    PolH DNA polymerase eta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolHprovided by FlyBase
    Official Full Name
    DNA polymerase etaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037141
    Locus tag
    Dmel_CG7143
    See related
    AllianceGenome:FB:FBgn0037141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF51794; CG7143; Dmel\CG7143; Dmpol eta; DNA pol eta; DNA pol-eta; DNApol-eta; DNApoleta; dPoleta; drad30A; pol eta; pol h; POLH
    Summary
    Enables DNA-directed DNA polymerase activity. Involved in UV protection; double-strand break repair; and translesion synthesis. Located in nucleus. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in female breast cancer and xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolH in Genome Data Viewer
    Location:
    79A4-79A4; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21938634..21941812, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21931734..21934912, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mushroom-body expressed Neighboring gene long non-coding RNA:CR43878 Neighboring gene long non-coding RNA:CR45959 Neighboring gene SLC22A family member Neighboring gene long non-coding RNA:CR45803 Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos. Lo Furno E, et al. Nucleic Acids Res, 2022 Jan 25. PMID 34939656, Free PMC Article
    2. Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota. Ishikawa T, et al. J Biol Chem, 2001 May 4. PMID 11297519
    3. Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. Kane DP, et al. PLoS Genet, 2012. PMID 22532806, Free PMC Article
    4. REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster. Khodaverdian V, et al. PLoS Genet, 2024 Jul. PMID 39074150, Free PMC Article
    5. The Spartan ortholog maternal haploid is required for paternal chromosome integrity in the Drosophila zygote. Delabaere L, et al. Curr Biol, 2014 Oct 6. PMID 25242033

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UV protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase eta
    Names
    CG7143-PA
    DNApol-eta
    PolH-PA
    polymerase eta
    NP_649371.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21938634..21941812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141114.3 → NP_649371.2  DNA polymerase eta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649371.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GNC0, Q9VNX1, T2GGD2
      Related
      FBpp0078142
      Conserved Domains (2) summary
      cd01702
      Location:20 → 447
      PolY_Pol_eta; DNA Polymerase eta
      pfam18439
      Location:805 → 832
      zf_UBZ; Ubiquitin-Binding Zinc Finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNX1.1 Q9VNX1

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