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    Rip11 Rab11 interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rip11provided by FlyBase
    Official Full Name
    Rab11 interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027335
    Locus tag
    Dmel_CG6606
    See related
    AllianceGenome:FB:FBgn0027335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6606; Dmel\CG6606; dRip11; l(1)G0003; l(1)G0070; l(1)G0092; l(1)G0205; l(1)G0297; l(1)G0434; rip11
    Summary
    Enables small GTPase binding activity. Involved in rhabdomere development. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in embryonic hypopharynx; larval muscle system; midline glial cell; midline primordium; and organism. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1); RAB11FIP2 (RAB11 family interacting protein 2); and RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rip11 in Genome Data Viewer
    Location:
    17C6-17C7; 1-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18635642..18647648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18529675..18541681, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44705 Neighboring gene wengen Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene Inhibitor of growth family, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuf and Rip11 requirement for polarity determinant recycling during Drosophila development. Calero-Cuenca FJ, et al. Small GTPases, 2018 Jul 4. PMID 27687567, Free PMC Article
    2. In vitro and in vivo characterization of the Rab11-GAP activity of Drosophila Evi5. Laflamme C, et al. Methods Mol Biol, 2015. PMID 25800843
    3. Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy. Miettinen TP, et al. Cell Rep, 2015 Dec 22. PMID 26686643, Free PMC Article
    4. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. Guichard A, et al. PLoS Pathog, 2017 Sep. PMID 28945820, Free PMC Article
    5. The motor function of Drosophila melanogaster myosin-5 is activated by calcium and cargo-binding protein dRab11. Ji HH, et al. Biochem J, 2015 Jul 1. PMID 25940004

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delivers morphogenic secretory traffic along polarized actin filaments of the subcortical terminal web to the exocytic plasma membrane target, the rhabdomere base.
      Title: Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rab11 interacting protein
    Names
    CG6606-PA
    CG6606-PB
    CG6606-PC
    CG6606-PD
    CG6606-PE
    Rip11-PA
    Rip11-PB
    Rip11-PC
    Rip11-PD
    Rip11-PE
    lethal (1) G0003

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18635642..18647648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169320.2 → NP_001162791.1  Rab11 interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494I2
      Conserved Domains (2) summary
      cd08682
      Location:7 → 130
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:352 → 399
      RBD-FIP; FIP domain

    2. NM_001298482.1 → NP_001285411.1  Rab11 interacting protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEA7
      Conserved Domains (2) summary
      cd08682
      Location:7 → 130
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:352 → 399
      RBD-FIP; FIP domain

    3. NM_001298484.1 → NP_001285413.1  Rab11 interacting protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFP6
      Conserved Domains (2) summary
      cd08682
      Location:7 → 130
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:758 → 805
      RBD-FIP; FIP domain

    4. NM_001298483.1 → NP_001285412.1  Rab11 interacting protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JL40
      Conserved Domains (2) summary
      cd08682
      Location:7 → 130
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:758 → 805
      RBD-FIP; FIP domain

    5. NM_133085.4 → NP_573313.2  Rab11 interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573313.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWS3
      Related
      FBpp0074387
      Conserved Domains (2) summary
      cd08682
      Location:7 → 130
      C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
      pfam09457
      Location:758 → 805
      RBD-FIP; FIP domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q494I2 Q494I2
    Q95SD9 Q95SD9
    Q9VWS3 Q9VWS3
    X2JEA7 X2JEA7
    X2JFP6 X2JFP6
    X2JL40 X2JL40

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