Cyt-c-d Cytochrome c distal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyt-c-dprovided by FlyBase
Official Full Name: Cytochrome c distalprovided by FlyBase
Primary source: FLYBASE:FBgn0086907
Locus tag: Dmel_CG13263
See related: AllianceGenome:FB:FBgn0086907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bln; bs30f07.y1; CG13263; CYC; cyt c; Cyt c; Cyt C; cyt c-d; cyt-c-d; Cyt-c1; cyt.c; cyt.c-d; Cytc; CytC; CYTC; CytC-1; cytc-d; Cytc-d; CytC1; cytochrome c; dc3; DC3; Dmel\CG13263; ms(2)04445; pDMc02
Summary: Enables cysteine-type endopeptidase activator activity involved in apoptotic process and electron transfer activity. Involved in regulation of compound eye retinal cell programmed cell death and sperm individualization. Located in cytosol and mitochondrion. Is expressed in several structures, including anterior-posterior subdivision of organism; larval brain; and spermatozoon. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16715891..16719635)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16715891..16719635)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

Names: CG13263-PA; CG13263-PB; Cyt-c-d-PA; Cyt-c-d-PB; blanks; cytochrome c; cytochrome c-d; cytochrome-c-d

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