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    kra krasavietz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kraprovided by FlyBase
    Official Full Name
    krasavietzprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250753
    Locus tag
    Dmel_CG2922
    See related
    AllianceGenome:FB:FBgn0250753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5MP; anon-WO0172774.49; CG2922; chr3R:1423015..1423173; CT7240; Decp; Dmel\CG2922; ecp; Ecp; ECP; eIF; eiF-5C; eIf-5c; eIF-5c; eIF-5C; eIF5; eIF5c; eIF5C; elf-5C; elF-5C; elF5C; exba; Exba; exba/kra; Kra; l(3)03022; l(3)j9B6
    Summary
    Enables ribosomal small subunit binding activity and translation initiation factor binding activity. Involved in several processes, including behavioral response to ethanol; long-term memory; and positive regulation of filopodium assembly. Located in several cellular components, including axonal growth cone; filopodium; and neuronal cell body. Is expressed in several structures, including adult head; central nervous system; dopaminergic PPL1 neuron; intrinsic neurons; and synaptic neuropil domain. Orthologous to several human genes including BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kra in Genome Data Viewer
    Location:
    83B4-83B4; 3-47.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5595364..5601136, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1421086..1426858, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase zeta subunit 2 Neighboring gene noisette Neighboring gene Vacuolar H[+]-ATPase 26kD subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sec synthetase Neighboring gene asterless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional connectivity and selective odor responses of excitatory local interneurons in Drosophila antennal lobe. Huang J, et al. Neuron, 2010 Sep 23. PMID 20869598
    2. Addiction-like behavior in Drosophila. Devineni AV, et al. Commun Integr Biol, 2010 Jul. PMID 20798826, Free PMC Article
    3. Crystallization and preliminary crystallographic studies of the W2 domain of Drosophila melanogaster eukaryotic translation initiation factor 5C domain-containing protein. Zhao H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Nov 1. PMID 23143239, Free PMC Article
    4. Physiological and morphological characterization of local interneurons in the Drosophila antennal lobe. Seki Y, et al. J Neurophysiol, 2010 Aug. PMID 20505124
    5. Electrical coupling between olfactory glomeruli. Yaksi E, et al. Neuron, 2010 Sep 23. PMID 20869599, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. preliminary crystallographic studies of the W2 domain of Drosophila melanogaster eukaryotic translation initiation factor 5C domain-containing protein
      Title: Crystallization and preliminary crystallographic studies of the W2 domain of Drosophila melanogaster eukaryotic translation initiation factor 5C domain-containing protein.
    2. Krasavietz mutants exhibit altered ethanol sensitivity, tolerance, and preference.
      Title: Preferential ethanol consumption in Drosophila models features of addiction.
    3. These data suggest that Kra(Exba)-mediated translational regulation plays important roles in midline axon repulsion and that Shot functions as a direct physical link between translational regulation and cytoskeleton reorganization.
      Title: The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    krasavietz
    Names
    CG2922-PA
    CG2922-PB
    CG2922-PC
    CG2922-PD
    CG2922-PE
    CG2922-PF
    CG2922-PG
    drosophila eIF5C-containing protein
    eIF5-mimic protein
    eukaryotic initiation factor 5C
    extra bases
    extra bses
    extra-bases
    kra-PA
    kra-PB
    kra-PC
    kra-PD
    kra-PE
    kra-PF
    kra-PG
    lethal (3) j9B6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5595364..5601136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169074.2 → NP_730958.1  krasavietz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078393
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    2. NM_079514.3 → NP_524238.1  krasavietz, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078394
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    3. NM_169075.2 → NP_730959.1  krasavietz, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078398
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    4. NM_169079.2 → NP_730963.1  krasavietz, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078396
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    5. NM_169076.2 → NP_730960.1  krasavietz, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078395
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    6. NM_169077.2 → NP_730961.1  krasavietz, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078397
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    7. NM_169078.2 → NP_730962.1  krasavietz, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F9, Q9VNE2
      Related
      FBpp0078399
      Conserved Domains (1) summary
      cd11560
      Location:218 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNE2.1 Q9VNE2

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