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    beta-Man beta-Mannosidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beta-Manprovided by FlyBase
    Official Full Name
    beta-Mannosidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037215
    Locus tag
    Dmel_CG12582
    See related
    AllianceGenome:FB:FBgn0037215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12582; CG12583; Dmel\CG12582
    Summary
    Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval salivary gland body; and salivary gland body primordium. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beta-Man in Genome Data Viewer
    Location:
    81F6-81F6; 3-47.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4197206..4204572)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22928..30294)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Drosulfakinin Neighboring gene uncharacterized protein Neighboring gene auxilin Neighboring gene uncharacterized protein Neighboring gene Dihydropterin deaminase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
    2. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
    3. Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation. Grobler Y, et al. PLoS Pathog, 2018 Nov. PMID 30422992, Free PMC Article
    4. Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases. Marcogliese PC, et al. Cell Rep, 2022 Mar 15. PMID 35294868, Free PMC Article
    5. Molecular and comparative genetics of mental retardation. Inlow JK, et al. Genetics, 2004 Feb. PMID 15020472, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 4201761-4201822 mobile_element_type = transposon:INE-1{}3625

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-mannosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-Mannosidase
    Names
    CG12582-PA
    CG12582-PD
    CG12582-PF
    CG12582-PG
    CG12582-PH
    beta-Man-PA
    beta-Man-PD
    beta-Man-PF
    beta-Man-PG
    beta-Man-PH
    NP_001246899.1
    NP_001262241.1
    NP_001262242.1
    NP_649436.2
    NP_730783.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4197206..4204572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275312.1 → NP_001262241.1  beta-Mannosidase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262241.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE6, Q8IGB2
      Conserved Domains (1) summary
      COG3250
      Location:60 → 590
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    2. NM_141179.4 → NP_649436.2  beta-Mannosidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649436.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGB2, Q9VMY5
      Related
      FBpp0078603
      Conserved Domains (1) summary
      COG3250
      Location:102 → 720
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    3. NM_001275313.1 → NP_001262242.1  beta-Mannosidase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGF7, Q8IGB2
      Conserved Domains (1) summary
      COG3250
      Location:102 → 720
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    4. NM_001259970.2 → NP_001246899.1  beta-Mannosidase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGB2, Q9VMY5
      Conserved Domains (1) summary
      COG3250
      Location:102 → 720
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    5. NM_164315.4 → NP_730783.3  beta-Mannosidase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730783.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIE6, Q8IGB2
      Conserved Domains (1) summary
      COG3250
      Location:60 → 590
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGF7 A0A0B4KGF7
    Q0KIE6 Q0KIE6
    Q5BI66 Q5BI66
    Q8IGB2 Q8IGB2
    Q95TA1 Q95TA1
    Q9VMY5 Q9VMY5

    Gene LinkOut

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