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    tbrd-2 testis-specifically expressed bromodomain containing protein-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbrd-2provided by FlyBase
    Official Full Name
    testis-specifically expressed bromodomain containing protein-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034423
    Locus tag
    Dmel_CG7229
    See related
    AllianceGenome:FB:FBgn0034423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7229; CG7229; Dmel\CG7229; tBrd-2; tBRD-2
    Summary
    Involved in spermatogenesis. Located in chromatin; nuclear body; and nucleolus. Is expressed in embryonic neuroblast; primary spermatocyte; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tbrd-2 in Genome Data Viewer
    Location:
    56C6-56C6; 2-88 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19259909..19262294)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15147414..15149799)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44432 Neighboring gene ribbon Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes. Kimura S, et al. Open Biol, 2015 Feb. PMID 25652540, Free PMC Article
    2. Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Brody T, et al. Dev Dyn, 2012 Jan. PMID 22174086, Free PMC Article
    3. Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. Hundertmark T, et al. PLoS One, 2019. PMID 30845228, Free PMC Article
    4. A Drosophila toolkit for defining gene function in spermatogenesis. Siddall NA, et al. Reproduction, 2017 Apr. PMID 28073824
    5. tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Theofel I, et al. Biol Open, 2017 Apr 15. PMID 28235844, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-specifically expressed bromodomain containing protein-2
    Names
    CG7229-PA
    gene 4
    tbrd-2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19259909..19262294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137557.3 → NP_611401.2  testis-specifically expressed bromodomain containing protein-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611401.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5A7, Q8T3Z8
      Related
      FBpp0085699
      Conserved Domains (1) summary
      cd05509
      Location:34 → 136
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V5A7 Q4V5A7
    Q8T3Z8 Q8T3Z8

    Gene LinkOut

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