coro Coronin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: coroprovided by FlyBase
Official Full Name: Coroninprovided by FlyBase
Primary source: FLYBASE:FBgn0265935
Locus tag: Dmel_CG9446
See related: AllianceGenome:FB:FBgn0265935
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9446; Dmel\CG9446; l(2)k08011
Summary: Predicted to enable actin filament binding activity. Involved in adult somatic muscle development and defense response to fungus. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; dorsal pharyngeal muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to several human genes including CORO1A (coronin 1A); CORO1B (coronin 1B); and CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42D6-42D6; 2-55 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6862001..6872718, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2749506..2760223, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning and characterization of coro, which codes for the Drosophila homologue of the F-actin binding protein coronin
Title: Genetic characterization of the Drosophila homologue of coronin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: coronin

Names: CG9446-PA; CG9446-PB; CG9446-PC; CG9446-PD; CG9446-PE; CG9446-PF; CG9446-PG; coro-PA; coro-PB; coro-PC; coro-PD; coro-PE; coro-PF; coro-PG; lethal (2) k08011

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6862001..6872718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136398.4 → NP_610242.1 coronin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610242.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVY0

Related

FBpp0085526

Conserved Domains (5) summary

PTZ00421
Location:9 → 485

PTZ00421; coronin; Provisional

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001273816.1 → NP_001260745.1 coronin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260745.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEJ7

Conserved Domains (4) summary

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001273815.1 → NP_001260744.1 coronin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260744.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEJ7

Conserved Domains (4) summary

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_165494.2 → NP_724509.1 coronin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724509.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVY0

Related

FBpp0085527

Conserved Domains (5) summary

PTZ00421
Location:9 → 485

PTZ00421; coronin; Provisional

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_206031.2 → NP_995753.1 coronin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995753.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVY0

Conserved Domains (5) summary

PTZ00421
Location:9 → 485

PTZ00421; coronin; Provisional

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001273813.1 → NP_001260742.1 coronin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260742.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEU5

Conserved Domains (5) summary

PTZ00421
Location:9 → 491

PTZ00421; coronin; Provisional

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:349 → 391

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 85

7WD40; WD40 repeat [structural motif]

cl02567
Location:85 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001273814.1 → NP_001260743.1 coronin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260743.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEJ7

Conserved Domains (4) summary

pfam08953
Location:7 → 64

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:37 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:79 → 294

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...