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    Ctf4 Chromosome transmission fidelity 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctf4provided by FlyBase
    Official Full Name
    Chromosome transmission fidelity 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0033890
    Locus tag
    Dmel_CG13350
    See related
    AllianceGenome:FB:FBgn0033890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.180; CG13350; Dmel\CG13350
    Summary
    Predicted to enable chromatin binding activity. Involved in DNA endoreduplication and preblastoderm mitotic cell cycle. Predicted to be active in nuclear replication fork. Is expressed in organism. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctf4 in Genome Data Viewer
    Location:
    50C23-50C23; 2-68 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13980362..13983317, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9867867..9870822, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Related to the N terminus of tre oncogene Neighboring gene mastermind Neighboring gene mir-4978 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression. Gosnell JA, et al. BMC Mol Biol, 2011 Apr 6. PMID 21470422, Free PMC Article
    2. Asymmetric Histone Inheritance: Establishment, Recognition, and Execution. Urban JA, et al. Annu Rev Genet, 2022 Nov 30. PMID 35905975, Free PMC Article
    3. Identification of PP2A-B55 targets uncovers regulation of emerin during nuclear envelope reassembly in Drosophila. Emond-Fraser V, et al. Open Biol, 2023 Jul. PMID 37463656, Free PMC Article
    4. Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A. Moshkin YM, et al. PLoS Genet, 2013. PMID 24086141, Free PMC Article
    5. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Moshkin YM, et al. Mol Cell, 2009 Sep 24. PMID 19782028

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in preblastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chromosome transmission fidelity 4
    Names
    CG13350-PA
    Ctf4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13980362..13983317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137077.4 → NP_610921.1  chromosome transmission fidelity 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY08, Q494K2
      Related
      FBpp0086732
      Conserved Domains (4) summary
      COG2319
      Location:1 → 304
      WD40; WD40 repeat [General function prediction only]
      pfam12341
      Location:393 → 670
      Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
      sd00039
      Location:16 → 52
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:12 → 256
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XY08 Q2XY08
    Q494K2 Q494K2
    Q95R77 Q95R77

    Gene LinkOut

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