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    Amyrel Amylase related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amyrelprovided by FlyBase
    Official Full Name
    Amylase relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020506
    Locus tag
    Dmel_CG8221
    See related
    AllianceGenome:FB:FBgn0020506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    amyrel; AmyRel; CG8221; Dmel\CG8221; melrel
    Summary
    Enables 4-alpha-glucanotransferase activity and alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in extracellular space. Orthologous to human AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Amyrel in Genome Data Viewer
    Location:
    53C14-53C14; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16651095..16652699, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12538600..12540204, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Anaplastic lymphoma kinase Neighboring gene gprs Neighboring gene nach Neighboring gene picot

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyphyly of the Zaprionus genus group (Diptera: Drosophilidae). Yassin A, et al. Mol Phylogenet Evol, 2010 Apr. PMID 19761854
    2. Amyrel, a novel glucose-forming α-amylase from Drosophila with 4-α-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides. Feller G, et al. Glycobiology, 2021 Sep 20. PMID 33978737
    3. A single amino-acid substitution toggles chloride dependence of the alpha-amylase paralog amyrel in Drosophila melanogaster and Drosophila virilis species. Claisse G, et al. Insect Biochem Mol Biol, 2016 Aug. PMID 27312592
    4. Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. Ambrosio L, et al. PLoS One, 2014. PMID 25133712, Free PMC Article
    5. Divergence between Drosophila santomea and allopatric or sympatric populations of D. yakuba using paralogous amylase genes and migration scenarios along the Cameroon volcanic line. Cariou ML, et al. Mol Ecol, 2001 Mar. PMID 11298976

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amyrel, a novel glucose-forming alpha-amylase from Drosophila with 4-alpha-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides.
      Title: Amyrel, a novel glucose-forming α-amylase from Drosophila with 4-α-glucanotransferase activity by disproportionation and hydrolysis of maltooligosaccharides.
    2. Amylolytic activity of Amyrel is about thirty times weaker than the classical Drosophila alpha-amylase, and the substitution of the arginine by a glutamine in D. melanogaster suppressed the chloride-dependence but was detrimental to activity. In contrast, changing the glutamine into an arginine rendered D. virilis Amyrel chloride-dependent, and interestingly, significantly increased its catalytic efficiency.
      Title: A single amino-acid substitution toggles chloride dependence of the alpha-amylase paralog amyrel in Drosophila melanogaster and Drosophila virilis species.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-amylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    amylase related
    Names
    Amyrel-PA
    CG8221-PA
    amyrel
    NP_477262.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16651095..16652699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057914.4 → NP_477262.1  amylase related [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477262.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18408, Q9V7S3
      Related
      FBpp0086263
      Conserved Domains (2) summary
      cd11317
      Location:29 → 398
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:404 → 492
      Aamy_C; Aamy_C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18408.2 O18408

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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