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    Alp1 Alkaline phosphatase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alp1provided by FlyBase
    Official Full Name
    Alkaline phosphatase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283479
    Locus tag
    Dmel_CG5656
    See related
    AllianceGenome:FB:FBgn0283479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aph; APH; Aph-1; CG5656; Dmel\CG5656; l-Aph; p-Aph
    Summary
    Enables alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal epidermis primordium; embryonic ventral epidermis; and epithelium. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPI (alkaline phosphatase, intestinal) and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alp1 in Genome Data Viewer
    Location:
    78D2-78D2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21442227..21444819, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21435327..21437919, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene barricade Neighboring gene uncharacterized protein Neighboring gene Adult enhancer factor 1 Neighboring gene uncharacterized protein Neighboring gene Syntaxin 7 Neighboring gene crocodile

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster: Inheritance of a Deficiency of Alkaline Phosphatase in Larvae. Johnson FM. Science, 1966 Apr 15. PMID 17775167
    2. VARIATIONS IN LARVAL ALKALINE PHOSPHATASE CONTROLLED BY APH ALLELES IN DROSOPHILA MELANOGASTER. BECKMAN L, et al. Genetics, 1964 May. PMID 14158614, Free PMC Article
    3. Alkaline phosphatase of Drosophila melanogaster. I. Partial purification and characterization. Harper RA, et al. Biochem Genet, 1972 Feb. PMID 4199796
    4. Alkaline phosphatase of Drosophila melanogaster. II. Biochemical comparison among four allelic forms. Harper RA, et al. Biochem Genet, 1973 Sep. PMID 4201108
    5. Alkaline phosphatase of Drosophila melanogaster. 3. Tyrosine-O-phosphate as substrate. Harper R, et al. Biochem Genet, 1974 Feb. PMID 4207495

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase 1
    Names
    Alp1-PA
    Alp1-PB
    CG5656-PA
    CG5656-PB
    alkaline phosphatase
    alkaline phosphatase-1
    larval alkaline phosphatase
    pupal alkaline phosphatase
    NP_001262159.1
    NP_649315.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21442227..21444819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141058.3 → NP_649315.1  alkaline phosphatase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZW8, Q9VP35
      Related
      FBpp0078050
      Conserved Domains (1) summary
      smart00098
      Location:65 → 507
      alkPPc; Alkaline phosphatase homologues

    2. NM_001275230.1 → NP_001262159.1  alkaline phosphatase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD70
      Conserved Domains (1) summary
      smart00098
      Location:65 → 514
      alkPPc; Alkaline phosphatase homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD70 M9PD70
    Q9VP35 Q9VP35

    Gene LinkOut

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