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    Nop10 Nop10 ribonucleoprotein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nop10provided by FlyBase
    Official Full Name
    Nop10 ribonucleoproteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033548
    Locus tag
    Dmel_CG7637
    See related
    AllianceGenome:FB:FBgn0033548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7637; Dmel\CG7637; NOP10
    Summary
    Predicted to enable telomerase RNA binding activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Predicted to be part of box H/ACA snoRNP complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; salivary gland body primordium; and trunk mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nop10 in Genome Data Viewer
    Location:
    47C1-47C1; 2-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10810556..10810936, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6698061..6698441, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene methuselah-like 13 Neighboring gene windei Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Methyl methanesulfonate sensitivity 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs. Laver JD, et al. Cell Rep, 2020 Mar 10. PMID 32160542
    2. Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis. Trowbridge K, et al. Genetics, 2007 Aug. PMID 17603121, Free PMC Article
    3. Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene Fork head. Maruyama R, et al. PLoS One, 2011. PMID 21698206, Free PMC Article
    4. Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation. Johnson PW, et al. Dev Biol, 2018 Aug 1. PMID 29679561, Free PMC Article
    5. Native purification of protein and RNA-protein complexes using a novel affinity procedure. Kroiss M, et al. Fly (Austin), 2009 Jul-Sep. PMID 19690462

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nop10 ribonucleoprotein
    Names
    CG7637-PA
    Nop10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10810556..10810936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136766.2 → NP_610610.1  Nop10 ribonucleoprotein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QPR2, Q9V5P6
      Related
      FBpp0087347
      Conserved Domains (1) summary
      pfam04135
      Location:4 → 52
      Nop10p; Nucleolar RNA-binding protein, Nop10p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V5P6.1 Q9V5P6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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