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    Nlg4 Neuroligin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nlg4provided by FlyBase
    Official Full Name
    Neuroligin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0083975
    Locus tag
    Dmel_CG34139
    See related
    AllianceGenome:FB:FBgn0083975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT13703; CG15682; CG15683; CG31209; CG31499; CG34139; CG5030; CG5035; Dmel\CG34139; dnlg4; Dnlg4; DNlg4; neuroligin; nlg4
    Summary
    Predicted to enable neurexin family protein binding activity and signaling receptor activity. Involved in GABAergic synaptic transmission and sleep. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in adult head; l-LNv neurons; larval brain; larval ventral nerve cord; and spermatozoon. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN1 (neuroligin 1); NLGN2 (neuroligin 2); and NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nlg4 in Genome Data Viewer
    Location:
    92D5-92D8; 3-68 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20204809..20245473)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16030531..16071195)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42836 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46043 Neighboring gene capicua Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroligins Nlg2 and Nlg4 Affect Social Behavior in Drosophila melanogaster. Corthals K, et al. Front Psychiatry, 2017. PMID 28740469, Free PMC Article
    2. Neurexin and neuroligins jointly regulate synaptic degeneration at the Drosophila neuromuscular junction based on TEM studies. Guangming G, et al. Front Cell Neurosci, 2023. PMID 38026694, Free PMC Article
    3. Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons. Chaturvedi R, et al. Curr Biol, 2022 May 9. PMID 35303417, Free PMC Article
    4. Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Dong T, et al. Proc Natl Acad Sci U S A, 2016 Jul 5. PMID 27335463, Free PMC Article
    5. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. Li Y, et al. J Neurosci, 2013 Sep 25. PMID 24068821, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neuroligin 4
    Names
    CG34139-PB
    CG34139-PC
    CG34139-PD
    CG34139-PE
    CG34139-PF
    Nlg4-PB
    Nlg4-PC
    Nlg4-PD
    Nlg4-PE
    Nlg4-PF
    neuroligin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20204809..20245473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300491.1 → NP_001287420.1  neuroligin 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDP5
      Conserved Domains (2) summary
      COG0657
      Location:151 → 259
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:43 → 681
      COesterase; Carboxylesterase family

    2. NM_001043265.2 → NP_001036730.2  neuroligin 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036730.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDP5
      Conserved Domains (2) summary
      COG0657
      Location:151 → 259
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:43 → 681
      COesterase; Carboxylesterase family

    3. NM_001170191.2 → NP_001163662.1  neuroligin 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDZ4
      Conserved Domains (2) summary
      COG0657
      Location:151 → 259
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:43 → 681
      COesterase; Carboxylesterase family

    4. NM_001170190.2 → NP_001163661.1  neuroligin 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDP5
      Conserved Domains (2) summary
      COG0657
      Location:151 → 259
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:43 → 681
      COesterase; Carboxylesterase family

    5. NM_001382070.1 → NP_001369025.1  neuroligin 4, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EDS1
      Conserved Domains (1) summary
      pfam00135
      Location:43 → 681
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EDS1 A0A6H2EDS1
    B6IDZ4 B6IDZ4
    Q8T468 Q8T468
    Q9VDP5 Q9VDP5

    Gene LinkOut

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