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    oprN multidrug efflux outer membrane protein OprN [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882885, updated on 24-Aug-2024

    Summary

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    Gene symbol
    oprN
    Gene description
    multidrug efflux outer membrane protein OprN
    Locus tag
    PA2495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2813194..2814612)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator MexT Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux transporter MexF Neighboring gene hypothetical protein Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa. Olivares J, et al. Antimicrob Agents Chemother, 2014 Jul. PMID 24777101, Free PMC Article
    2. Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa. Broutin I, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Mar 1. PMID 16511029, Free PMC Article
    3. Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography. Lambert O, et al. J Struct Biol, 2005 Apr. PMID 15797729
    4. Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa. Maseda H, et al. FEMS Microbiol Lett, 2010 Oct. PMID 20727012
    5. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we determined that the early activation of the nitrate respiratory chain under aerobic conditions plays a role in preventing a deleterious effect associated with the overexpression of MexEF-OprN
      Title: Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa.
    2. Transcription of the mexEF-oprN multidrug efflux pump operon is regulated by MexT.
      Title: Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa.
    3. OprM and OprN belong to the outer membrane factor family proteins which have been expressed in Escherichia coli and purified.
      Title: Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa.
    4. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
      Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
    5. Two-dimensional (2D) crystallization of OprN into lipid bilayers and the determination of its 2D projected structure by cryo-electron crystallography.
      Title: Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    multidrug efflux outer membrane protein OprN
    NP_251185.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2813194..2814612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251185.1 multidrug efflux outer membrane protein OprN [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251185.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      P95423
      Conserved Domains (1) summary
      COG1538
      Location:20 → 472
      TolC; Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
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