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    SAP18 SIN3 associated polypeptide P18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819172, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAP18
    Official Full Name
    SIN3 associated polypeptide P18
    Primary source
    TAIR:AT2G45640
    Locus tag
    AT2G45640
    See related
    Araport:AT2G45640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSAP18; F17K2.17; SIN3 ASSOCIATED POLYPEPTIDE 18; SIN3 associated polypeptide P18
    Summary
    Involved in the regulation of salt stress. Expression of AtSAP18 is induced by NaCl, cold, drought, ABA, and ethylene treatment. AtSAP18 and HDA19 associate with ERF3 and ERF4 both in vitro and in vivo.
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    Genomic context

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    See SAP18 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18799528..18801471, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene D-isomer specific 2-hydroxyacid dehydrogenase family protein Neighboring gene miscRNA Neighboring gene AGAMOUS-like 6 Neighboring gene AGAMOUS-like 20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis. Song CP, et al. Plant Mol Biol, 2006 Jan. PMID 16429262
    2. Regulation of floral patterning by flowering time genes. Liu C, et al. Dev Cell, 2009 May. PMID 19460347
    3. A transcriptional repression motif in the MADS factor AGL15 is involved in recruitment of histone deacetylase complex components. Hill K, et al. Plant J, 2008 Jan. PMID 17999645
    4. Photoperiodic regulation of flowering time through periodic histone deacetylation of the florigen gene FT. Gu X, et al. PLoS Biol, 2013 Sep. PMID 24019760, Free PMC Article
    5. Arabidopsis ACINUS is O-glycosylated and regulates transcription and alternative splicing of regulators of reproductive transitions. Bi Y, et al. Nat Commun, 2021 Feb 11. PMID 33574257, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202824.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SIN3 associated polypeptide P18
    NP_001189753.1
    • SIN3 associated polypeptide P18 (SAP18); FUNCTIONS IN: protein binding, transcription regulator activity; INVOLVED IN: response to salt stress, response to abscisic acid stimulus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sin3 associated polypeptide p18 (InterPro:IPR010516), Histone deacetylase complex, SAP18 subunit (InterPro:IPR017250).
    NP_566050.1
    • SIN3 associated polypeptide P18 (SAP18); FUNCTIONS IN: protein binding, transcription regulator activity; INVOLVED IN: response to salt stress, response to abscisic acid stimulus; LOCATED IN: nucleolus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sin3 associated polypeptide p18 (InterPro:IPR010516), Histone deacetylase complex, SAP18 subunit (InterPro:IPR017250); Has 294 Blast hits to 294 proteins in 125 species: Archae - 0; Bacteria - 0; Metazoa - 174; Fungi - 52; Plants - 40; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18799528..18801471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130126.4 → NP_566050.1  SIN3 associated polypeptide P18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64644, Q0WTU2, Q8L8K8
      UniProtKB/TrEMBL
      A0A178VW39, A0A5S9X7B0
      Conserved Domains (1) summary
      pfam06487
      Location:32 → 151
      SAP18; Sin3 associated polypeptide p18 (SAP18)

    2. NM_001202824.1 → NP_001189753.1  SIN3 associated polypeptide P18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IG85
      Conserved Domains (1) summary
      pfam06487
      Location:37 → 148
      SAP18; Sin3 associated polypeptide p18 (SAP18)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64644.1

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