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    CPFTSY signal recognition particle receptor protein, chloroplast (FTSY) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819185, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPFTSY
    Official Full Name
    signal recognition particle receptor protein, chloroplast (FTSY)
    Primary source
    TAIR:AT2G45770
    Locus tag
    AT2G45770
    See related
    Araport:AT2G45770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALPHA SUBUNIT CPFTSY; CHLOROPLAST SRP RECEPTOR HOMOLOG; F4I18.25; FERRIC CHELATE REDUCTASE DEFECTIVE 4; FRD4
    Summary
    chloroplast SRP receptor homolog, alpha subunit CPFTSY. Required for LHCP integration into isolated thylakoids.
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    Genomic context

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    See CPFTSY in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (18851088..18853741)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene BON association protein 2 Neighboring gene ncRNA Neighboring gene phosphomannomutase Neighboring gene GATA type zinc finger transcription factor family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity. Marty NJ, et al. J Biol Chem, 2009 May 29. PMID 19293157, Free PMC Article
    2. The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site. Stengel KF, et al. FEBS Lett, 2007 Dec 11. PMID 18022392
    3. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Nguyen TX, et al. Biochemistry, 2011 Aug 23. PMID 21780778, Free PMC Article
    4. Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis. Asakura Y, et al. Plant J, 2008 Dec. PMID 18764927
    5. Efficient interaction between two GTPases allows the chloroplast SRP pathway to bypass the requirement for an SRP RNA. Jaru-Ampornpan P, et al. Mol Biol Cell, 2007 Jul. PMID 17475780, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cpFtsY membrane-binding motif plays a critical role in the intramolecular communication that regulates cpSRP receptor functions at the membrane.
      Title: The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity.
    2. cpftsY mutants generally exhibit defects in the biogenesis of light-harvesting chlorophyll proteins and other thylakoidal membrane proteins that are less severe than in the alb3 mutants.
      Title: Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis.
    3. the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution.
      Title: The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site.
    4. These results highlight intriguing differences between the classical and chloroplast SRP and SRP receptor GTPases, and help explain how the chloroplast SRP pathway can mediate efficient targeting of proteins to the thylakoid membrane.
      Title: Efficient interaction between two GTPases allows the chloroplast SRP pathway to bypass the requirement for an SRP RNA.
    5. Mutations within the cpFtsY gene are associated with an inability to induce Fe(III) chelate reductase activity in response to iron deficiency.
      Title: Arabidopsis cpFtsY mutants exhibit pleiotropic defects including an inability to increase iron deficiency-inducible root Fe(III) chelate reductase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130140.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within photosynthetic electron transport in photosystem II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast thylakoid membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    signal recognition particle receptor protein, chloroplast (FTSY)
    NP_566056.1
    • CPFTSY; FUNCTIONS IN: nucleoside-triphosphatase activity, GTP binding, nucleotide binding; INVOLVED IN: protein import into chloroplast thylakoid membrane, protein targeting, thylakoid membrane organization, photosynthetic electron transport in photosystem II; LOCATED IN: chloroplast, signal recognition particle, endoplasmic reticulum targeting, chloroplast thylakoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), Signal recognition particle, SRP54 subunit, helical bundle (InterPro:IPR013822), Signal recognition particle, SRP54 subunit, GTPase (InterPro:IPR000897), Cell division transporter substrate-binding protein FtsY (InterPro:IPR004390); BEST Arabidopsis thaliana protein match is: chloroplast signal recognition particle 54 kDa subunit (TAIR:AT5G03940.1); Has 16847 Blast hits to 16846 proteins in 2926 species: Archae - 468; Bacteria - 10588; Metazoa - 346; Fungi - 290; Plants - 258; Viruses - 1; Other Eukaryotes - 4896 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18851088..18853741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130140.3 → NP_566056.1  signal recognition particle receptor protein, chloroplast (FTSY) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566056.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IH43, O80842, Q9SWS7, Q9XFR1
      UniProtKB/TrEMBL
      A0A178VSN3, A0A5S9X7C5, A0A654F2A5
      Conserved Domains (1) summary
      PRK10416
      Location:48 → 365
      PRK10416; signal recognition particle-docking protein FtsY; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80842.2

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