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    QPT quinolinate phoshoribosyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814663, updated on 18-Sep-2024

    Summary

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    Official Symbol
    QPT
    Official Full Name
    quinolinate phoshoribosyltransferase
    Primary source
    TAIR:AT2G01350
    Locus tag
    AT2G01350
    See related
    Araport:AT2G01350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10A8.23; F10A8_23; quinolinate phoshoribosyltransferase
    Summary
    At2g01350 encodes quinolinate phosphoribosyl transferase involved in NAD biosynthesis as shown by heterologous expression in E. coli.
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    Genomic context

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    See QPT in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (165141..167259, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ABC-2 type transporter family protein Neighboring gene nucleotide binding protein Neighboring gene plastid movement impaired protein Neighboring gene pentatricopeptide (PPR) repeat protein Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid. Katoh A, et al. Plant Physiol, 2006 Jul. PMID 16698895, Free PMC Article
    2. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084395.1
    NM_001084396.1
    NM_126196.3
    NM_201664.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within NAD biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    quinolinate phoshoribosyltransferase
    NP_001077864.1
    • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5825 Blast hits to 5825 proteins in 1916 species: Archae - 184; Bacteria - 3588; Metazoa - 59; Fungi - 124; Plants - 57; Viruses - 0; Other Eukaryotes - 1813 (source: NCBI BLink).
    NP_001077865.1
    • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5862 Blast hits to 5862 proteins in 1918 species: Archae - 184; Bacteria - 3596; Metazoa - 59; Fungi - 124; Plants - 57; Viruses - 0; Other Eukaryotes - 1842 (source: NCBI BLink).
    NP_565259.1
    • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5853 Blast hits to 5853 proteins in 1914 species: Archae - 184; Bacteria - 3582; Metazoa - 59; Fungi - 129; Plants - 57; Viruses - 0; Other Eukaryotes - 1842 (source: NCBI BLink).
    NP_973393.1
    • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      165141..167259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126196.3 → NP_565259.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LC11, Q93ZA4, Q9ZU32
      UniProtKB/TrEMBL
      A0A178VX18, A0A5S9WWD9, A0A7G2E7G9
      Conserved Domains (1) summary
      PLN02716
      Location:29 → 336
      PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)

    2. NM_001084395.1 → NP_001077864.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E7G9, A8MRX1
      Conserved Domains (2) summary
      PLN02716
      Location:29 → 330
      PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)
      cd01572
      Location:48 → 326
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...

    3. NM_201664.2 → NP_973393.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4INA0
      Conserved Domains (2) summary
      cd01572
      Location:1 → 265
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
      TIGR00078
      Location:2 → 266
      nadC; nicotinate-nucleotide pyrophosphorylase

    4. NM_001084396.1 → NP_001077865.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E7G9, A8MS71
      Conserved Domains (2) summary
      PLN02716
      Location:8 → 315
      PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)
      cd01572
      Location:27 → 311
      QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZU32.2

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