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    ULP1D UB-like protease 1D [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842317, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ULP1D
    Official Full Name
    UB-like protease 1D
    Primary source
    TAIR:AT1G60220
    Locus tag
    AT1G60220
    See related
    Araport:AT1G60220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    OTS1; OVERLY TOLERANT TO SALT 1; T13D8.11; T13D8_11; UB-like protease 1D
    Summary
    Encodes a deSUMOylating enzyme. In vitro it has both peptidase activity and isopeptidase activity: it can cleave C-terminal residues from SUMO to activate it for attachment to a target protein and it can also act on the isopeptide bond between SUMO and another protein. sGFP:OTS1 protein accumulates in the nucleus. Double mutant analysis with ULP1C/OTS2 indicates that these genes are involved in salt stress responses and flowering time regulation. Over-expression of 35S:OTS1 increases salt tolerance and reduces the level of SUMO-conjugated proteins. OTS1 transcript levels do not appear to change in response to salt, but, salt stress reduces the level of OTS1 protein in a proteasome-dependent manner.
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    Genomic context

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    See ULP1D in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (22208089..22212171)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene splicing factor PWI domain-containing protein / RNA recognition motif (RRM)-containing protein Neighboring gene Radical SAM superfamily protein Neighboring gene NAC (No Apical Meristem) domain transcriptional regulator superfamily protein Neighboring gene B-box zinc finger family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OTS1-dependent deSUMOylation increases tolerance to high copper levels in Arabidopsis. Zhan E, et al. J Integr Plant Biol, 2018 Apr. PMID 29205850
    2. Transcriptional Gene Silencing Maintained by OTS1 SUMO Protease Requires a DNA-Dependent Polymerase V-Dependent Pathway. Liu L, et al. Plant Physiol, 2017 Jan. PMID 27852949, Free PMC Article
    3. SUMO proteases OTS1 and 2 control filament elongation through a DELLA-dependent mechanism. Campanaro A, et al. Plant Reprod, 2016 Dec. PMID 27761651
    4. Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana. Bailey M, et al. J Exp Bot, 2016 Jan. PMID 26494731, Free PMC Article
    5. Small ubiquitin-like modifier proteases OVERLY TOLERANT TO SALT1 and -2 regulate salt stress responses in Arabidopsis. Conti L, et al. Plant Cell, 2008 Oct. PMID 18849491, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OTS1, a protease that cleaves SUMO from its substrate proteins, participates in Cu tolerance in Arabidopsis thaliana (Arabidopsis).
      Title: OTS1-dependent deSUMOylation increases tolerance to high copper levels in Arabidopsis.
    2. OTS1 SUMO protease activity is required for regulating aberrant gene silence.
      Title: Transcriptional Gene Silencing Maintained by OTS1 SUMO Protease Requires a DNA-Dependent Polymerase V-Dependent Pathway.
    3. The OTS genes are proposed to enable synchronization of stamen development by facilitating DELLA degradation at a specific developmental stage.
      Title: SUMO proteases OTS1 and 2 control filament elongation through a DELLA-dependent mechanism.
    4. OTS1 and -2 act in a feedback loop in salicylic acid (SA) signalling and that de novo OTS1/2 synthesis works antagonistically to SA-promoted degradation, adjusting the abundance of OTS1/2 to moderate SA signalling.
      Title: Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana.
    5. OTS1 and OTS2 are SUMO proteases which are localized to the nucleus and regulate salt stress responses in Arabidopsis. [OTS1]
      Title: Small ubiquitin-like modifier proteases OVERLY TOLERANT TO SALT1 and -2 regulate salt stress responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104712.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    UB-like protease 1D
    NP_176228.3
    • UB-like protease 1D (ULP1D); CONTAINS InterPro DOMAIN/s: Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro:IPR003653); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT1G10570.2); Has 2556 Blast hits to 2339 proteins in 246 species: Archae - 0; Bacteria - 12; Metazoa - 1276; Fungi - 441; Plants - 318; Viruses - 13; Other Eukaryotes - 496 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22208089..22212171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104712.5 → NP_176228.3  UB-like protease 1D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176228.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80745, Q2PS26
      UniProtKB/TrEMBL
      A0A654ELB1, A0A7G2DZ00
      Conserved Domains (1) summary
      pfam02902
      Location:357 → 560
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PS26.1

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