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    CNX2 cofactor of nitrate reductase and xanthine dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817754, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CNX2
    Official Full Name
    cofactor of nitrate reductase and xanthine dehydrogenase 2
    Primary source
    TAIR:AT2G31955
    Locus tag
    AT2G31955
    See related
    Araport:AT2G31955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT2G31950; cofactor of nitrate reductase and xanthine dehydrogenase 2; F22D22.30; F22D22_30
    Summary
    COFACTOR OF NITRATE REDUCTASE AND XANTHINE DEHYDROGENASE 2. Encodes a protein involved in molybdenum cofactor biosynthesis. Homologous to E.coli moaA. Expression is abundant in all tissues examined, particularly in roots. Appears to have targeting signals for chloroplast or mitochondria.
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    Genomic context

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    See CNX2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (13583985..13586703, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene oxidoreductase/transition metal ion-binding protein Neighboring gene uncharacterized protein Neighboring gene low-molecular-weight cysteine-rich 76 Neighboring gene ncRNA Neighboring gene low-molecular-weight cysteine-rich 75 Neighboring gene glucan synthase-like 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria. Kruse I, et al. Biochem J, 2018 Jan 31. PMID 29247140, Free PMC Article
    2. Characterisation of Arabidopsis calnexin 1 and calnexin 2 in the endoplasmic reticulum and at plasmodesmata. Liu DY, et al. Protoplasma, 2017 Jan. PMID 26680228
    3. Visualization and quantification of protein interactions in the biosynthetic pathway of molybdenum cofactor in Arabidopsis thaliana. Kaufholdt D, et al. J Exp Bot, 2013 Apr. PMID 23630326, Free PMC Article
    4. Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis. Vu KV, et al. Plant J, 2017 Mar. PMID 27888524
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data functionally characterize CNX2 and suggest that ATM3 is indirectly required for cyclic pyranopterin monophosphate biosynthesis.
      Title: Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria.
    2. The abnormal phenotype of the cnx1 crt1 crt2 crt3 quadruple mutants was completely rescued by either the CNX1 or CNX2 cDNA under the control of the CNX1 promoter, suggesting functional redundancy between CNX1 and CNX2. Taken together, these results provide genetic evidence that CNX and CRT play essential and overlapping roles during vegetative growth and male gametophyte development in Arabidopsis
      Title: Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis.
    3. CNX1 and CNX2 do not appear to have a specific localisation or function at plasmodesmata-rather the association of calnexin with the endoplasmic reticulum (ER) is simply maintained as the ER passes through plasmodesmata.
      Title: Characterisation of Arabidopsis calnexin 1 and calnexin 2 in the endoplasmic reticulum and at plasmodesmata.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001202723.1
    NM_001336357.1
    NM_001336359.1
    NM_179846.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP 3',8'-cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cofactor of nitrate reductase and xanthine dehydrogenase 2
    NP_001031461.1
    • cofactor of nitrate reductase and xanthine dehydrogenase 2 (CNX2); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor synthesis C-terminal (InterPro:IPR010505), Aldolase-type TIM barrel (InterPro:IPR013785), Elongator protein 3/MiaB/NifB (InterPro:IPR006638), Molybdenum cofactor biosynthesis protein A (InterPro:IPR013483), Radical SAM (InterPro:IPR007197), MoaA/nifB/pqqE, iron-sulphur binding, conserved site (InterPro:IPR000385); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001189652.1
    • cofactor of nitrate reductase and xanthine dehydrogenase 2 (CNX2); CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Molybdenum cofactor synthesis C-terminal (InterPro:IPR010505), Elongator protein 3/MiaB/NifB (InterPro:IPR006638), Molybdenum cofactor biosynthesis protein A (InterPro:IPR013483), Radical SAM (InterPro:IPR007197), MoaA/nifB/pqqE, iron-sulphur binding, conserved site (InterPro:IPR000385).
    NP_850177.2
    • cofactor of nitrate reductase and xanthine dehydrogenase 2 (CNX2); CONTAINS InterPro DOMAIN/s: Molybdenum cofactor synthesis C-terminal (InterPro:IPR010505), Aldolase-type TIM barrel (InterPro:IPR013785), Elongator protein 3/MiaB/NifB (InterPro:IPR006638), Molybdenum cofactor biosynthesis protein A (InterPro:IPR013483), Radical SAM (InterPro:IPR007197), MoaA/nifB/pqqE, iron-sulphur binding, conserved site (InterPro:IPR000385); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13583985..13586703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036384.2 → NP_001031461.1  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031461.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IRV0, Q39055, Q8LBF4
      UniProtKB/TrEMBL
      A0A178W0P6, A0A5S9X323, A0A7G2EGJ2
      Conserved Domains (1) summary
      PLN02951
      Location:5 → 390
      PLN02951; Molybderin biosynthesis protein CNX2

    2. NM_001336358.1 → NP_001324731.1  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IRV0, Q39055, Q8LBF4
      UniProtKB/TrEMBL
      A0A178W0P6, A0A5S9X323, A0A7G2EGJ2
      Conserved Domains (1) summary
      PLN02951
      Location:5 → 390
      PLN02951; Molybderin biosynthesis protein CNX2

    3. NM_179846.4 → NP_850177.2  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850177.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IRV0, Q39055, Q8LBF4
      UniProtKB/TrEMBL
      A0A178W0P6, A0A5S9X323, A0A7G2EGJ2
      Conserved Domains (1) summary
      PLN02951
      Location:5 → 390
      PLN02951; Molybderin biosynthesis protein CNX2

    4. NM_001336357.1 → NP_001324733.1  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B110, A0A7G2EGJ2

    5. NM_001336359.1 → NP_001324732.1  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B110, A0A7G2EGJ2

    6. NM_001202723.1 → NP_001189652.1  cofactor of nitrate reductase and xanthine dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EGJ2
      Conserved Domains (3) summary
      cd01335
      Location:79 → 256
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:5 → 382
      PLN02951; Molybderin biosynthesis protein CNX2
      pfam06463
      Location:246 → 364
      Mob_synth_C; Molybdenum Cofactor Synthesis C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39055.1

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