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    ATNTH1 DNA glycosylase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817703, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATNTH1
    Official Full Name
    DNA glycosylase superfamily protein
    Primary source
    TAIR:AT2G31450
    Locus tag
    AT2G31450
    See related
    Araport:AT2G31450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T28P16.6; T28P16_6
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    Genomic context

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    See ATNTH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (13401132..13404222, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene gamma-secretase subunit APH1-like protein Neighboring gene B3 domain protein, putative (DUF313) Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, expression and functional characterization of an Arabidopsis thaliana homologue of the Escherichia coli DNA repair enzyme endonuclease III. Roldán-Arjona T, et al. Plant Mol Biol, 2000 Sep. PMID 11094978
    2. Evidence for base excision repair of oxidative DNA damage in chloroplasts of Arabidopsis thaliana. Gutman BL, et al. J Biol Chem, 2009 Jun 19. PMID 19372224, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001084519.1
    NM_128702.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA glycosylase superfamily protein
    NP_001077988.1
    • ATNTH1; CONTAINS InterPro DOMAIN/s: Helix-hairpin-helix motif (InterPro:IPR000445), Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), Endonuclease III, iron-sulphur binding site (InterPro:IPR004035), DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), Endonuclease III, conserved site-2 (InterPro:IPR004036), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: endonuclease III 2 (TAIR:AT1G05900.2); Has 14133 Blast hits to 14127 proteins in 2683 species: Archae - 365; Bacteria - 9377; Metazoa - 224; Fungi - 192; Plants - 158; Viruses - 0; Other Eukaryotes - 3817 (source: NCBI BLink).
    NP_565725.1
    • ATNTH1; CONTAINS InterPro DOMAIN/s: Helix-hairpin-helix motif (InterPro:IPR000445), Helix-hairpin-helix DNA-binding motif, class 1 (InterPro:IPR003583), Endonuclease III, iron-sulphur binding site (InterPro:IPR004035), DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), Endonuclease III, conserved site-2 (InterPro:IPR004036), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: endonuclease III 2 (TAIR:AT1G05900.2); Has 14067 Blast hits to 14061 proteins in 2669 species: Archae - 367; Bacteria - 9308; Metazoa - 224; Fungi - 193; Plants - 158; Viruses - 0; Other Eukaryotes - 3817 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13401132..13404222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128702.3 → NP_565725.1  DNA glycosylase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LF57, Q8VZT5, Q9FT83, Q9SIC4
      UniProtKB/TrEMBL
      A0A5S9X365, A0A654EXU8
      Conserved Domains (3) summary
      smart00525
      Location:339 → 359
      FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
      COG0177
      Location:173 → 362
      Nth; Endonuclease III [Replication, recombination and repair]
      cd00056
      Location:174 → 336
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases

    2. NM_001084519.1 → NP_001077988.1  DNA glycosylase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X365, A0A654EXU8
      Conserved Domains (3) summary
      smart00525
      Location:337 → 357
      FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
      COG0177
      Location:171 → 360
      Nth; Endonuclease III [Replication, recombination and repair]
      cd00056
      Location:172 → 334
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIC4.2

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