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    ALDH5F1 aldehyde dehydrogenase 5F1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844282, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALDH5F1
    Official Full Name
    aldehyde dehydrogenase 5F1
    Primary source
    TAIR:AT1G79440
    Locus tag
    AT1G79440
    See related
    Araport:AT1G79440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aldehyde dehydrogenase 5F1; ENF1; ENLARGED FIL EXPRESSION DOMAIN 1; SSADH; SSADH1; SUCCINIC SEMIALDEHYDE DEHYDROGENASE; SUCCINIC SEMIALDEHYDE DEHYDROGENASE 1
    Summary
    Encodes a mitochondrial succinic semialdehyde dehydrogenase (SSADH). Nomenclature according to Kirch, et al (2004).
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    Genomic context

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    See ALDH5F1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (29882121..29887414, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene C-type mannose receptor (DUF620) Neighboring gene Homeodomain-like superfamily protein Neighboring gene ALA-interacting subunit 5 Neighboring gene Terpenoid cyclases/Protein prenyltransferases superfamily protein Neighboring gene Aldolase-type TIM barrel family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Busch KB, et al. Plant Physiol, 1999 Oct. PMID 10517851, Free PMC Article
    2. Plant succinic semialdehyde dehydrogenase: dissection of nucleotide binding by surface plasmon resonance and fluorescence spectroscopy. Busch K, et al. Biochemistry, 2000 Aug 22. PMID 10955999
    3. Transcript and metabolite profiling during cold acclimation of Arabidopsis reveals an intricate relationship of cold-regulated gene expression with modifications in metabolite content. Kaplan F, et al. Plant J, 2007 Jun. PMID 17461790
    4. GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants. Fait A, et al. FEBS Lett, 2005 Jan 17. PMID 15642352
    5. Mitochondrial succinic-semialdehyde dehydrogenase of the gamma-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Bouché N, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12740438, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ENF1 gene encodes SUCCINIC SEMIALDEHYDE DEHYDROGENASE (SSADH), which catalyzes the conversion of succinic semialdehyde (SSA) to succinate.
      Title: Succinic semialdehyde dehydrogenase is involved in the robust patterning of Arabidopsis leaves along the adaxial-abaxial axis.
    2. Data suggest that POP2 mutants suppress the phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
      Title: Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106592.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaxial/abaxial axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyrate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyrate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of shoot apical meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase 5F1
    NP_178062.1
    • aldehyde dehydrogenase 5F1 (ALDH5F1); FUNCTIONS IN: 3-chloroallyl aldehyde dehydrogenase activity, NAD or NADH binding, copper ion binding, succinate-semialdehyde dehydrogenase activity; INVOLVED IN: in 6 processes; LOCATED IN: mitochondrion, chloroplast, mitochondrial matrix; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Aldehyde dehydrogenase (InterPro:IPR015590), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, conserved site (InterPro:IPR016160), Succinic semialdehyde dehydrogenase (InterPro:IPR010102); BEST Arabidopsis thaliana protein match is: aldehyde dehydrogenase 2B4 (TAIR:AT3G48000.1); Has 62487 Blast hits to 62143 proteins in 3037 species: Archae - 481; Bacteria - 36218; Metazoa - 2614; Fungi - 2131; Plants - 1502; Viruses - 0; Other Eukaryotes - 19541 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29882121..29887414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106592.5 → NP_178062.1  aldehyde dehydrogenase 5F1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SAK4, Q9SEK4
      UniProtKB/TrEMBL
      A0A178W894, A0A654EVI1
      Conserved Domains (1) summary
      PLN02278
      Location:29 → 526
      PLN02278; succinic semialdehyde dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAK4.2

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