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    HIK ATP binding microtubule motor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838418, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HIK
    Official Full Name
    ATP binding microtubule motor family protein
    Primary source
    TAIR:AT1G18370
    Locus tag
    AT1G18370
    See related
    Araport:AT1G18370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS NPK1-ACTIVATING KINESIN 1; ATNACK1; F15H18.12; F15H18_12; HINKEL; NACK1; NPK1-ACTIVATING KINESIN 1
    Summary
    Encodes a kinesin HINKEL. Required for cytokinesis in pollen. Mutant has cytokinesis defects; seedling lethal.
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    Genomic context

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    See HIK in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (6319450..6324378, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene basal transcription factor complex subunit-like protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene MAP kinase kinase 7 Neighboring gene Serine/Threonine kinase family catalytic domain protein Neighboring gene ncRNA Neighboring gene BR enhanced expression 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The carboxyl-terminal tail of the stalk of Arabidopsis NACK1/HINKEL kinesin is required for its localization to the cell plate formation site. Sasabe M, et al. J Plant Res, 2015 Mar. PMID 25502072, Free PMC Article
    2. The microtubule-associated kinase-like protein RUNKEL functions in somatic and syncytial cytokinesis. Krupnova T, et al. Plant J, 2013 Jun. PMID 23451828
    3. Arabidopsis kinesins HINKEL and TETRASPORE act redundantly to control cell plate expansion during cytokinesis in the male gametophyte. Oh SA, et al. Mol Plant, 2008 Sep. PMID 19825582
    4. The AtNACK1/HINKEL and STUD/TETRASPORE/AtNACK2 genes, which encode functionally redundant kinesins, are essential for cytokinesis in Arabidopsis. Tanaka H, et al. Genes Cells, 2004 Dec. PMID 15569152
    5. Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants. Sasabe M, et al. Proc Natl Acad Sci U S A, 2011 Oct 25. PMID 22006334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using dissected Arabidopsis NACK1 molecules and AtNACK1-fused GFP, it was shown that the C-terminal tail of the stalk in addition to the motor domain is critical for its proper localization to the site of cell plate formation in the phragmoplast.
      Title: The carboxyl-terminal tail of the stalk of Arabidopsis NACK1/HINKEL kinesin is required for its localization to the cell plate formation site.
    2. Cytokinesis in A. thaliana is controlled by a pathway that includes HIK and a MAP kinase cascade that consists of ANPs and MKK6/ANQ.
      Title: HINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana.
    3. data demonstrate a functionally redundant role for HIK and TES in cell plate expansion during male gametophytic cytokinesis.
      Title: Arabidopsis kinesins HINKEL and TETRASPORE act redundantly to control cell plate expansion during cytokinesis in the male gametophyte.
    4. AtNACK1/HINKEL appears to be an essential component of a MAP kinase cascade that promotes cytokinesis of plant cells.
      Title: The AtNACK1/HINKEL and STUD/TETRASPORE/AtNACK2 genes, which encode functionally redundant kinesins, are essential for cytokinesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101695.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac cellularization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gametophyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP binding microtubule motor family protein
    NP_173273.2
    • HINKEL (HIK); FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: response to cyclopentenone, cellularization of the embryo sac, gametophyte development, pollen development, cytokinesis; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3490 (InterPro:IPR021881), Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G43210.1); Has 14045 Blast hits to 12964 proteins in 525 species: Archae - 35; Bacteria - 375; Metazoa - 6535; Fungi - 1633; Plants - 1984; Viruses - 5; Other Eukaryotes - 3478 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6319450..6324378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101695.5 → NP_173273.2  ATP binding microtubule motor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173273.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S905, Q9LPQ5
      UniProtKB/TrEMBL
      A0A5S9V2P1, A0A654ELQ3
      Conserved Domains (3) summary
      cd01374
      Location:31 → 353
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
      pfam00225
      Location:37 → 353
      Kinesin; Kinesin motor domain
      pfam11995
      Location:792 → 955
      DUF3490; Domain of unknown function (DUF3490)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S905.1

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