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    ARK2 armadillo repeat kinesin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839306, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARK2
    Official Full Name
    armadillo repeat kinesin 2
    Primary source
    TAIR:AT1G01950
    Locus tag
    AT1G01950
    See related
    Araport:AT1G01950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana KINESIN Ungrouped clade; armadillo repeat kinesin 2; AtKINUb; F22M8.8; F22M8_8; gene B
    Summary
    Encodes a member of the armadillo/beta-catenin repeat kinesin motor family. Mutants have twisted roots due to abnormal cell file rotation; the phenotype is dependent on microtubules.
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    Genomic context

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    See ARK2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (325316..330619)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene SET domain-containing protein Neighboring gene zinc finger protein-like protein Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene SEC7-like guanine nucleotide exchange family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene FAD-binding Berberine family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stable ARMADILLO REPEAT KINESIN 2 in light inhibits hypocotyl elongation and facilitates light-induced cortical microtubule reorientation in Arabidopsis. Lan M, et al. J Exp Bot, 2023 Feb 5. PMID 36453983
    2. ARK2 stabilizes the plus-end of microtubules and promotes microtubule bundling in Arabidopsis. Lan M, et al. J Integr Plant Biol, 2023 Jan. PMID 36169006
    3. Armadillo repeat-containing kinesins and a NIMA-related kinase are required for epidermal-cell morphogenesis in Arabidopsis. Sakai T, et al. Plant J, 2008 Jan. PMID 17971038
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stable ARMADILLO REPEAT KINESIN 2 in light inhibits hypocotyl elongation and facilitates light-induced cortical microtubule reorientation in Arabidopsis.
      Title: Stable ARMADILLO REPEAT KINESIN 2 in light inhibits hypocotyl elongation and facilitates light-induced cortical microtubule reorientation in Arabidopsis.
    2. ARK2 stabilizes the plus-end of microtubules and promotes microtubule bundling in Arabidopsis.
      Title: ARK2 stabilizes the plus-end of microtubules and promotes microtubule bundling in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001160828.1
    NM_001160829.1
    NM_001331317.1
    NM_100075.8

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat kinesin 2
    NP_001154300.1
    • armadillo repeat kinesin 2 (ARK2); FUNCTIONS IN: microtubule motor activity, binding, ATP binding; INVOLVED IN: root development; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: armadillo repeat kinesin 3 (TAIR:AT1G12430.1); Has 17581 Blast hits to 15249 proteins in 612 species: Archae - 56; Bacteria - 561; Metazoa - 7371; Fungi - 1920; Plants - 2768; Viruses - 17; Other Eukaryotes - 4888 (source: NCBI BLink).
    NP_001154301.1
    • armadillo repeat kinesin 2 (ARK2); FUNCTIONS IN: microtubule motor activity, binding, ATP binding; INVOLVED IN: root development; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: armadillo repeat kinesin 3 (TAIR:AT1G12430.1); Has 18598 Blast hits to 15978 proteins in 689 species: Archae - 52; Bacteria - 737; Metazoa - 7861; Fungi - 1903; Plants - 2828; Viruses - 15; Other Eukaryotes - 5202 (source: NCBI BLink).
    NP_171697.3
    • armadillo repeat kinesin 2 (ARK2); FUNCTIONS IN: microtubule motor activity, binding, ATP binding; INVOLVED IN: root development; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: armadillo repeat kinesin 3 (TAIR:AT1G12430.1); Has 19604 Blast hits to 16795 proteins in 739 species: Archae - 69; Bacteria - 853; Metazoa - 8320; Fungi - 2122; Plants - 2828; Viruses - 22; Other Eukaryotes - 5390 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      325316..330619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100075.8 → NP_171697.3  armadillo repeat kinesin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171697.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9CP40, Q0WMY6, Q9LPC6
      UniProtKB/TrEMBL
      A0A178W9D2, A0A5S9S5Q3, A0A654E657
      Conserved Domains (4) summary
      TIGR01612
      Location:326 → 587
      235kDa-fam; reticulocyte binding/rhoptry protein
      PLN03200
      Location:630 → 749
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:638 → 663
      ARM; armadillo repeat [structural motif]
      pfam00225
      Location:66 → 402
      Kinesin; Kinesin motor domain

    2. NM_001331317.1 → NP_001320318.1  armadillo repeat kinesin 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AMI8, A0A5S9S5Q3, A0A654E657

    3. NM_001160829.1 → NP_001154301.1  armadillo repeat kinesin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9S5Q3, A0A654E657, F4HU83
      Conserved Domains (6) summary
      cd00020
      Location:653 → 769
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00106
      Location:60 → 400
      KISc; Kinesin motor domain
      pfam00225
      Location:66 → 402
      Kinesin; Kinesin motor domain
      pfam10481
      Location:409 → 593
      CENP-F_N; Cenp-F N-terminal domain
      sd00043
      Location:659 → 684
      ARM; armadillo repeat [structural motif]
      cl19297
      Location:413 → 487
      Dor1; Dor1-like family

    4. NM_001160828.1 → NP_001154300.1  armadillo repeat kinesin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9S5Q3, A0A654E657, F4HU85
      Conserved Domains (6) summary
      cd00020
      Location:615 → 731
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00106
      Location:60 → 400
      KISc; Kinesin motor domain
      pfam00225
      Location:66 → 402
      Kinesin; Kinesin motor domain
      pfam10481
      Location:409 → 576
      CENP-F_N; Cenp-F N-terminal domain
      sd00043
      Location:621 → 646
      ARM; armadillo repeat [structural motif]
      cl19297
      Location:413 → 487
      Dor1; Dor1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPC6.2

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