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    Neutral/alkaline non-lysosomal ceramidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837250, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Neutral/alkaline non-lysosomal ceramidase
    Primary source
    TAIR:AT1G07380
    Locus tag
    AT1G07380
    See related
    Araport:AT1G07380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22G5.28; F22G5_28
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (2264634..2269121, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein Neighboring gene proliferating cellular nuclear antigen 1 Neighboring gene receptor like protein 1 Neighboring gene HSP20-like chaperones superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress. Li J, et al. Front Plant Sci, 2015. PMID 26150824, Free PMC Article
    2. The Arabidopsis ceramidase AtACER functions in disease resistance and salt tolerance. Wu JX, et al. Plant J, 2015 Mar. PMID 25619405
    3. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_100612.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular sphingolipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Neutral/alkaline non-lysosomal ceramidase
    NP_172218.1
    • Neutral/alkaline non-lysosomal ceramidase; FUNCTIONS IN: ceramidase activity; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Neutral/alkaline nonlysosomal ceramidase (InterPro:IPR006823); BEST Arabidopsis thaliana protein match is: Neutral/alkaline non-lysosomal ceramidase (TAIR:AT5G58980.1); Has 713 Blast hits to 570 proteins in 199 species: Archae - 0; Bacteria - 295; Metazoa - 184; Fungi - 101; Plants - 78; Viruses - 0; Other Eukaryotes - 55 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2264634..2269121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331696.1 → NP_001321129.1  Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKR2, A0A1P8APY2

    2. NM_100612.2 → NP_172218.1  Neutral/alkaline non-lysosomal ceramidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172218.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HQM3, Q9LNV7
      UniProtKB/TrEMBL
      A0A178WKR2
      Conserved Domains (2) summary
      pfam04734
      Location:37 → 611
      Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
      pfam17048
      Location:613 → 778
      Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HQM3.1

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