HTR12 Histone superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HTR12
Official Full Name: Histone superfamily protein
Primary source: TAIR:AT1G01370
Locus tag: AT1G01370
See related: Araport:AT1G01370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CENH3; CENTROMERIC HISTONE H3; F6F3.17; F6F3_17
Summary: Encodes a centromere-identifying protein histone H3 variant. Localized at centromeres in both mitotic and meiotic cells.
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Genomic context

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See HTR12 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (143489..146479)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat stress promotes haploid formation during CENH3-mediated genome elimination in Arabidopsis.
Title: Heat stress promotes haploid formation during CENH3-mediated genome elimination in Arabidopsis.
Extreme divergence in CENH3 protein sequence does not alter centromere location in Arabidopsis.
Title: Centromere location in Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence.
Arabidopsis KNL2 colocalizes with cenH3 and is associated with centromeres during all stages of the mitotic cell cycle, except from metaphase to mid-anaphase.
Title: Arabidopsis kinetochore null2 is an upstream component for centromeric histone H3 variant cenH3 deposition at centromeres.
Reduced endogenous CENH3 and lack of meiotic incorporation of EYFP-CENH3(C) lead to reduced fertility caused by insufficient CENH3 loading to the centromeres of meiotic chromosomes, subsequent lagging of chromosomes and formation of micronuclei.
Title: Knockdown of CENH3 in Arabidopsis reduces mitotic divisions and causes sterility by disturbed meiotic chromosome segregation.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
Title: Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
CENH3 is expressed in dividing tissues and is CENH3 is transcriptionally regulated by E2F/DP transcription factors.
Title: The E2F transcription factor family regulates CENH3 expression in Arabidopsis thaliana.
Deposition of Arabidopsis CENH3 takes place at centromeres during G2.
Title: Deposition, turnover, and release of CENH3 at Arabidopsis centromeres.
Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana
Title: Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana.
study concludes that CENH3 function in A. thaliana, an organism with large tandem repeat centromeres, has stringent requirements for functional complementation in mitosis
Title: The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana.
Alignment of CENH3 sequences revealed that the tested species share only three amino acids at loop1 region: threonine2, arginine12 and alanine15
Title: Recognition of A. thaliana centromeres by heterologous CENH3 requires high similarity to the endogenous protein.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001035850.3

Supported by ESTs:

NM_001331270.1

Supported by ESTs:

NM_100019.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within centromere complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double fertilization forming a zygote and endosperm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Histone superfamily protein

NP_001030927.1

HTR12; FUNCTIONS IN: DNA binding; INVOLVED IN: double fertilization forming a zygote and endosperm; LOCATED IN: chromosome, centromeric region, nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3 (InterPro:IPR000164), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: male-gamete-specific histone H3 (TAIR:AT1G19890.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_563627.1

HTR12; FUNCTIONS IN: DNA binding; INVOLVED IN: double fertilization forming a zygote and endosperm; LOCATED IN: chromosome, centromeric region, nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Histone H3 (InterPro:IPR000164), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: male-gamete-specific histone H3 (TAIR:AT1G19890.1); Has 14361 Blast hits to 14354 proteins in 7190 species: Archae - 0; Bacteria - 0; Metazoa - 10494; Fungi - 2020; Plants - 1256; Viruses - 0; Other Eukaryotes - 591 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

143489..146479

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001331269.1 → NP_001322867.1 Histone superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LCW8, Q8RVQ9, Q9LNI6

UniProtKB/TrEMBL

A0A178WB57, A0A5S9S2J6

Conserved Domains (1) summary

cl23735
Location:72 → 173

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
NM_001035850.3 → NP_001030927.1 Histone superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030927.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LCW8, Q8RVQ9, Q9LNI6

UniProtKB/TrEMBL

A0A178WB57, A0A5S9S2J6

Conserved Domains (1) summary

cl23735
Location:72 → 173

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
NM_100019.2 → NP_563627.1 Histone superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563627.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LCW8, Q8RVQ9, Q9LNI6

UniProtKB/TrEMBL

A0A178WB57, A0A5S9S2J6

Conserved Domains (1) summary

cl23735
Location:72 → 173

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
NM_001331270.1 → NP_001322868.1 Histone superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LCW8, Q8RVQ9, Q9LNI6

UniProtKB/TrEMBL

A0A178WB57, A0A5S9S2J6

Conserved Domains (1) summary

cl23735
Location:72 → 173

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...