U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SPPA signal peptide peptidase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843737, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SPPA
    Official Full Name
    signal peptide peptidase
    Primary source
    TAIR:AT1G73990
    Locus tag
    AT1G73990
    See related
    Araport:AT1G73990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2P9.14; F2P9_14; signal peptide peptidase; SPPA1
    Summary
    Encodes a putative protease SppA (SppA).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SPPA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (27824355..27829039)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene CLAVATA3/ESR-RELATED 13 Neighboring gene obscurin-like protein Neighboring gene Phosphoribulokinase / Uridine kinase family Neighboring gene strictosidine synthase 3 Neighboring gene Calcium-dependent phosphotriesterase superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Yeast-based reporter assay system for identifying the requirements of intramembrane proteolysis by signal peptide peptidase of Arabidopsis thaliana. Kusunoki K, et al. FEBS Open Bio, 2020 Sep. PMID 32686366, Free PMC Article
    2. Loss of chloroplast protease SPPA function alters high light acclimation processes in Arabidopsis thaliana L. (Heynh.). Wetzel CM, et al. J Exp Bot, 2009. PMID 19349419, Free PMC Article
    3. Identification and characterization of SppA, a novel light-inducible chloroplast protease complex associated with thylakoid membranes. Lensch M, et al. J Biol Chem, 2001 Sep 7. PMID 11443110
    4. The signal peptide peptidase is required for pollen function in Arabidopsis. Han S, et al. Plant Physiol, 2009 Mar. PMID 19168645, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast-based reporter assay system for identifying the requirements of intramembrane proteolysis by signal peptide peptidase of Arabidopsis thaliana.
      Title: Yeast-based reporter assay system for identifying the requirements of intramembrane proteolysis by signal peptide peptidase of Arabidopsis thaliana.
    2. Loss of SPPA affects photoprotective mechanisms during high light acclimation.
      Title: Loss of chloroplast protease SPPA function alters high light acclimation processes in Arabidopsis thaliana L. (Heynh.).
    3. AtSPP is required for male gametophyte development and pollen maturation in Arabidopsis.
      Title: The signal peptide peptidase is required for pollen function in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_001334622.1
    NM_106058.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal peptide peptidase
    NP_565077.2
    • signal peptide peptidase (SPPA); FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: proteolysis, response to light intensity; LOCATED IN: chloroplast thylakoid membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S49, protease IV (InterPro:IPR004634), Peptidase S49 (InterPro:IPR002142), Peptidase S49, SppA (InterPro:IPR004635); Has 9340 Blast hits to 7649 proteins in 1706 species: Archae - 204; Bacteria - 6183; Metazoa - 9; Fungi - 4; Plants - 52; Viruses - 43; Other Eukaryotes - 2845 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27824355..27829039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106058.3 → NP_565077.2  signal peptide peptidase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565077.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H187, Q9C9C0, Q9SEL8
      UniProtKB/TrEMBL
      A0A178WBG0, A0A5S9WU63
      Conserved Domains (2) summary
      cd07023
      Location:375 → 590
      S49_Sppa_N_C; Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad
      TIGR00705
      Location:122 → 639
      SppA_67K; signal peptide peptidase SppA, 67K type

    2. NM_001334622.1 → NP_001322608.1  signal peptide peptidase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUG2
      Conserved Domains (2) summary
      cd07018
      Location:128 → 341
      S49_SppA_67K_type; Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad
      cd07023
      Location:375 → 553
      S49_Sppa_N_C; Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9C0.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools