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    NHX2 sodium hydrogen exchanger 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NHX2
    Official Full Name
    sodium hydrogen exchanger 2
    Primary source
    TAIR:AT3G05030
    Locus tag
    AT3G05030
    See related
    Araport:AT3G05030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNHX2; sodium hydrogen exchanger 2; T9J14.2; T9J14_2
    Summary
    Encodes a vacuolar K+/H+ exchanger essential for active K+ uptake at the tonoplast and involved in regulating stomatal closure.
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    Genomic context

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    See NHX2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (1393142..1397627, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein of unknown function, transmembrane-40 Neighboring gene acyl carrier protein 1 Neighboring gene ncRNA Neighboring gene exportin-4 protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis. Barragán V, et al. Plant Cell, 2012 Mar. PMID 22438021, Free PMC Article
    2. The Arabidopsis Na+/H+ antiporters NHX1 and NHX2 control vacuolar pH and K+ homeostasis to regulate growth, flower development, and reproduction. Bassil E, et al. Plant Cell, 2011 Sep. PMID 21954467, Free PMC Article
    3. Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters. Bassil E, et al. Plant Physiol, 2019 Feb. PMID 30498025, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHX2 is a main contributor to both vacuolar pH and K(+) and Na(+) uptake.
      Title: Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters.
    2. Tonoplast-localized NHX1 and NHX2 proteins are essential for active K+ uptake at the tonoplast, for turgor regulation, and for stomatal function.
      Title: Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis.
    3. NHX1 and NHX2 mediate K+/H+ exchange to accumulate K+ in the vacuole. NHX1 and NHX2 function together to control cell expansion in vegetative tissues and male reproductive organs and are required for normal flower development.
      Title: The Arabidopsis Na+/H+ antiporters NHX1 and NHX2 control vacuolar pH and K+ homeostasis to regulate growth, flower development, and reproduction.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001337553.1
    NM_001337554.1
    NM_001337555.1
    NM_111375.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of stomatal closure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    sodium hydrogen exchanger 2
    NP_001319475.1
    • sodium hydrogen exchanger 2 (NHX2); FUNCTIONS IN: sodium:hydrogen antiporter activity, sodium ion transmembrane transporter activity; INVOLVED IN: cation transport, sodium ion transport, regulation of pH, transmembrane transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 1-4, conserved region (InterPro:IPR018407); BEST Arabidopsis thaliana protein match is: Na+/H+ exchanger 1 (TAIR:AT5G27150.1); Has 5239 Blast hits to 5232 proteins in 1555 species: Archae - 25; Bacteria - 3481; Metazoa - 811; Fungi - 131; Plants - 434; Viruses - 0; Other Eukaryotes - 357 (source: NCBI BLink).
    NP_187154.1
    • sodium hydrogen exchanger 2 (NHX2); FUNCTIONS IN: sodium:hydrogen antiporter activity, sodium ion transmembrane transporter activity; INVOLVED IN: cation transport, sodium ion transport, regulation of pH, transmembrane transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Na+/H+ exchanger, subfamily (InterPro:IPR004709), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 1-4, conserved region (InterPro:IPR018407); BEST Arabidopsis thaliana protein match is: Na+/H+ exchanger 1 (TAIR:AT5G27150.1); Has 5612 Blast hits to 5606 proteins in 1611 species: Archae - 51; Bacteria - 3727; Metazoa - 852; Fungi - 131; Plants - 439; Viruses - 0; Other Eukaryotes - 412 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1393142..1397627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111375.4 → NP_187154.1  sodium hydrogen exchanger 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XP4, Q9CAW6
      UniProtKB/TrEMBL
      A0A178VK10, A0A5S9X997
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 444
      b_cpa1; sodium/hydrogen exchanger 3

    2. NM_001337554.1 → NP_001326211.1  sodium hydrogen exchanger 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VK89, A0A1I9LNK7, A0A384LNZ4
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 401
      b_cpa1; sodium/hydrogen exchanger 3

    3. NM_001337553.1 → NP_001319475.1  sodium hydrogen exchanger 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XP4, Q9CAW6
      UniProtKB/TrEMBL
      A0A178VK10, A0A5S9X997
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 444
      b_cpa1; sodium/hydrogen exchanger 3

    4. NM_001337555.1 → NP_001326210.1  sodium hydrogen exchanger 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XP4, Q9CAW6
      UniProtKB/TrEMBL
      A0A178VK10, A0A5S9X997
      Conserved Domains (1) summary
      TIGR00840
      Location:46 → 444
      b_cpa1; sodium/hydrogen exchanger 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56XP4.2

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