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    SUN2 SAD1/UNC-84 domain protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820242, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUN2
    Official Full Name
    SAD1/UNC-84 domain protein 2
    Primary source
    TAIR:AT3G10730
    Locus tag
    AT3G10730
    See related
    Araport:AT3G10730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 2; ATSUN2; SAD1/UNC-84 domain protein 2
    Summary
    Encodes a member of the Sad1/UNC-84 (SUN)-domain proteins: AtSUN1(At5g04990), AtSUN2(AT3G10730). SUN domain proteins are part of the cytoskeletal-nucleoskeletal bridging complexes. AtSUN1 and AtSUN2 are localized to the nuclear envelope and are present as homomers and heteromers in vivo.
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    Genomic context

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    See SUN2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (3358288..3360702, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene root hair specific 12 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene alpha-L-arabinofuranosidase 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the role that SUN proteins may play in pollen nuclear migration
      Title: SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility.
    2. The nuclear envelope localization of SUN1, SUN2, WIP1, and a truncated WIT2 does not depend on CRWN1.
      Title: Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
    3. associations between AtLINC1 and plant SUN proteins
      Title: Evidence for LINC1-SUN associations at the plant nuclear periphery.
    4. SUN1 and SUN2 are necessary for the maintenance and/or formation of polarized nuclear shape in root hairs.
      Title: Dynamics of Arabidopsis SUN proteins during mitosis and their involvement in nuclear shaping.
    5. Results indicate that AtSUN2 contain the highly conserved C-terminal SUN domain, localize to and show low mobility in the nuclear envelope (NE), particularly in the inner nuclear membrane.
      Title: Characterization of SUN-domain proteins at the higher plant nuclear envelope.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111910.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic attachment of telomere to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear envelope HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast HDA PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    SAD1/UNC-84 domain protein 2
    NP_566380.2
    • SAD1/UNC-84 domain protein 2 (SUN2); FUNCTIONS IN: protein binding; INVOLVED IN: biological_process unknown; LOCATED IN: nuclear envelope, endoplasmic reticulum, phragmoplast, spindle; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Sad1/UNC-like, C-terminal (InterPro:IPR012919); BEST Arabidopsis thaliana protein match is: SAD1/UNC-84 domain protein 1 (TAIR:AT5G04990.1); Has 537 Blast hits to 534 proteins in 132 species: Archae - 4; Bacteria - 39; Metazoa - 349; Fungi - 35; Plants - 67; Viruses - 0; Other Eukaryotes - 43 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3358288..3360702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111910.4 → NP_566380.2  SAD1/UNC-84 domain protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566380.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L9I5, Q9SG79
      UniProtKB/TrEMBL
      A0A178V772, A0A5S9XAV5
      Conserved Domains (2) summary
      COG1340
      Location:145 → 266
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam07738
      Location:310 → 445
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SG79.1

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