U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ABCC8 multidrug resistance-associated protein 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821679, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ABCC8
    Official Full Name
    multidrug resistance-associated protein 6
    Primary source
    TAIR:AT3G21250
    Locus tag
    AT3G21250
    See related
    Araport:AT3G21250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 6; ATMRP6; ATP-binding cassette C8; MRP6; multidrug resistance-associated protein 6
    Summary
    member of MRP subfamily
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ABCC8 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (7457433..7463644, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 5 Neighboring gene 4-coumarate:CoA ligase 2 Neighboring gene ncRNA Neighboring gene Glycolipid transfer protein (GLTP) family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. AtMRP6/AtABCC6, an ATP-binding cassette transporter gene expressed during early steps of seedling development and up-regulated by cadmium in Arabidopsis thaliana. Gaillard S, et al. BMC Plant Biol, 2008 Feb 28. PMID 18307782, Free PMC Article
    2. The Arabidopsis thaliana ABC protein superfamily, a complete inventory. Sánchez-Fernández R, et al. J Biol Chem, 2001 Aug 10. PMID 11346655
    3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results of this study suggest that MRP6 is part of a cluster involved in metal tolerance, although additional functions in planta cannot be discarded.
      Title: AtMRP6/AtABCC6, an ATP-binding cassette transporter gene expressed during early steps of seedling development and up-regulated by cadmium in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_113020.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuolar membrane HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    multidrug resistance-associated protein 6
    NP_001189944.1
    • multidrug resistance-associated protein 6 (MRP6); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 14 (TAIR:AT3G59140.1).
    NP_188762.3
    • multidrug resistance-associated protein 6 (MRP6); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, plant-type vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 14 (TAIR:AT3G59140.1); Has 598023 Blast hits to 338310 proteins in 3899 species: Archae - 10844; Bacteria - 482752; Metazoa - 12132; Fungi - 7443; Plants - 6523; Viruses - 16; Other Eukaryotes - 78313 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7457433..7463644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338518.1 → NP_001326629.1  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPV5, A0A654F9A4

    2. NM_001338517.1 → NP_001326627.1  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPV3

    3. NM_001203015.2 → NP_001189944.1  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGU1, Q9LU34
      UniProtKB/TrEMBL
      A0A5S9XEM3
      Conserved Domains (4) summary
      cd03244
      Location:1213 → 1433
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:598 → 798
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      PLN03232
      Location:32 → 1447
      PLN03232; ABC transporter C family member; Provisional
      cl00549
      Location:900 → 1165
      ABC_membrane; ABC transporter transmembrane region

    4. NM_001338520.1 → NP_001326628.1  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPV3

    5. NM_001338519.1 → NP_001326630.1  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPV6, A0A654F9A4

    6. NM_113020.3 → NP_188762.3  multidrug resistance-associated protein 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188762.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XEM3
      Conserved Domains (4) summary
      cd03244
      Location:1202 → 1422
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:598 → 782
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      PLN03232
      Location:32 → 1436
      PLN03232; ABC transporter C family member; Provisional
      cl00549
      Location:889 → 1154
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGU1.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.