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    EHD1 EPS15 homology domain 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821573, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EHD1
    Official Full Name
    EPS15 homology domain 1
    Primary source
    TAIR:AT3G20290
    Locus tag
    AT3G20290
    See related
    Araport:AT3G20290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEHD1; EPS15 homology domain 1
    Summary
    Encodes AtEHD1, one of the Arabidopsis Eps15 homology domain proteins involved in endocytosis (AtEHD2, At4g05520).
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    Genomic context

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    See EHD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (7074764..7079014, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene lipid-binding serum glycoprotein family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene extracellular ligand-gated ion channel protein (DUF3537) Neighboring gene ethylene response factor 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EHD1 functions in endosomal recycling and confers salt tolerance. Bar M, et al. PLoS One, 2013. PMID 23342166, Free PMC Article
    2. AtEHDs, novel Arabidopsis EH-domain-containing proteins involved in endocytosis. Bar M, et al. Plant J, 2008 Sep. PMID 18547399
    3. Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Uno Y, et al. Mol Genet Genomics, 2009 Apr. PMID 19130088
    4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035654.2
    NM_001338474.1
    NM_112920.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    EPS15 homology domain 1
    NP_001030731.1
    • EPS15 homology domain 1 (EHD1); FUNCTIONS IN: GTP binding, GTPase activity, calcium ion binding; INVOLVED IN: endocytosis; LOCATED IN: endosome, microsome, membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-HAND 2 (InterPro:IPR018249), EPS15 homology (EH) (InterPro:IPR000261), Dynamin, GTPase domain (InterPro:IPR001401), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: EPS15 homology domain 2 (TAIR:AT4G05520.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566657.1
    • EPS15 homology domain 1 (EHD1); FUNCTIONS IN: GTP binding, GTPase activity, calcium ion binding; INVOLVED IN: endocytosis; LOCATED IN: endosome, microsome, membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-HAND 2 (InterPro:IPR018249), EPS15 homology (EH) (InterPro:IPR000261), Dynamin, GTPase domain (InterPro:IPR001401), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: EPS15 homology domain 2 (TAIR:AT4G05520.1); Has 2747 Blast hits to 1834 proteins in 266 species: Archae - 2; Bacteria - 80; Metazoa - 1639; Fungi - 521; Plants - 217; Viruses - 0; Other Eukaryotes - 288 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7074764..7079014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035654.2 → NP_001030731.1  EPS15 homology domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030731.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94CF0, Q9LTR4
      UniProtKB/TrEMBL
      A0A178VAZ5, A0A5S9XDX4
      Conserved Domains (4) summary
      cd09913
      Location:199 → 443
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:19 → 85
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:163 → 195
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:435 → 537
      DUF5600; Domain of unknown function (DUF5600)

    2. NM_001338474.1 → NP_001327849.1  EPS15 homology domain 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94CF0, Q9LTR4
      UniProtKB/TrEMBL
      A0A178VAZ5, A0A5S9XDX4
      Conserved Domains (4) summary
      cd09913
      Location:199 → 443
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:19 → 85
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:163 → 195
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:435 → 537
      DUF5600; Domain of unknown function (DUF5600)

    3. NM_112920.4 → NP_566657.1  EPS15 homology domain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94CF0, Q9LTR4
      UniProtKB/TrEMBL
      A0A178VAZ5, A0A5S9XDX4
      Conserved Domains (4) summary
      cd09913
      Location:199 → 443
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:19 → 85
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:163 → 195
      EHD_N; N-terminal EH-domain containing protein
      pfam18150
      Location:435 → 537
      DUF5600; Domain of unknown function (DUF5600)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94CF0.1

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