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    2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820564, updated on 18-Sep-2024

    Summary

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    Official Full Name
    2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein
    Primary source
    TAIR:AT3G13610
    Locus tag
    AT3G13610
    See related
    Araport:AT3G13610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6'H1
    Summary
    Encodes a Fe(II)- and 2-oxoglutarate-dependent dioxygenase family gene F6'H1. Mutations in this gene compromise iron uptake and the production of fluorescent phenolics involved in Fe uptake.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (4449259..4450811)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene calmodulin-binding family protein Neighboring gene Amino acid permease family protein Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana. Sun X, et al. Sci Rep, 2015 May 20. PMID 25993561, Free PMC Article
    2. Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis. Schmid NB, et al. Plant Physiol, 2014 Jan. PMID 24246380, Free PMC Article
    3. Hydrogen peroxide-induced cell death in Arabidopsis: transcriptional and mutant analysis reveals a role of an oxoglutarate-dependent dioxygenase gene in the cell death process. Gechev TS, et al. IUBMB Life, 2005 Mar. PMID 16036580
    4. Mutually exclusive alterations in secondary metabolism are critical for the uptake of insoluble iron compounds by Arabidopsis and Medicago truncatula. Rodríguez-Celma J, et al. Plant Physiol, 2013 Jul. PMID 23735511, Free PMC Article
    5. Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana. Kai K, et al. Plant J, 2008 Sep. PMID 18547395

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of F6'H1 towards 4-coumaroyl-CoA was not improved by introducing those mutations, indicating that besides TYR 151 and VAL 238, the subtle difference between the overall structures of F6'H1 and C2'H is also important for substrate specificity.
      Title: Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana.
    2. At3g13610 is essential for tolerance of Arabidopsis to high pH-induced Fe deficiency.
      Title: Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.
    3. F6'H1/At3G13610 is a 2-oxoglutarate-dependent dioxygenase which synthesizes scopoletin by ortho-hydroxylation of feruloyl CoA.
      Title: Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_112207.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within coumarin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in coumarin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to iron ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein
    NP_187970.1
    • 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT1G55290.1); Has 8779 Blast hits to 8731 proteins in 1013 species: Archae - 0; Bacteria - 1145; Metazoa - 121; Fungi - 1057; Plants - 4989; Viruses - 0; Other Eukaryotes - 1467 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4449259..4450811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112207.4 → NP_187970.1  2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187970.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LHN8
      UniProtKB/TrEMBL
      A0A178V671, A0A5S9XBU7
      Conserved Domains (1) summary
      PLN02393
      Location:27 → 357
      PLN02393; leucoanthocyanidin dioxygenase like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LHN8.1

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