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    MAC3B MOS4-associated complex 3B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817897, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAC3B
    Official Full Name
    MOS4-associated complex 3B
    Primary source
    TAIR:AT2G33340
    Locus tag
    AT2G33340
    See related
    Araport:AT2G33340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4P9.11; F4P9_11; MOS4-associated complex 3B; MOS4-associated complex 3B
    Summary
    Encodes MAC3B, a U-box proteins with homology to the yeast and human E3 ubiquitin ligase Prp19. Associated with the MOS4-Associated Complex (MAC). Involved in plant innate immunity.
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    Genomic context

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    See MAC3B in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Sequence:
    Chromosome: 2; NC_003071.7 (14126141..14131224, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene plasmodesmata-located protein 3 Neighboring gene ncRNA Neighboring gene CCT motif family protein Neighboring gene cadherin EGF LAG seven-pass G-type receptor, putative (DUF3527)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis. Li S, et al. Plant Cell, 2018 Feb. PMID 29437988, Free PMC Article
    2. E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis. Guo X, et al. Plant Physiol, 2024 Jan 31. PMID 37850874, Free PMC Article
    3. A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis. Feke AM, et al. Genetics, 2020 Jul. PMID 32434795, Free PMC Article
    4. Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity. Monaghan J, et al. PLoS Pathog, 2009 Jul. PMID 19629177, Free PMC Article
    5. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Deng X, et al. Proc Natl Acad Sci U S A, 2016 May 10. PMID 27114555, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis.
      Title: E3 ligases MAC3A and MAC3B ubiquitinate UBIQUITIN-SPECIFIC PROTEASE14 to regulate organ size in Arabidopsis.
    2. A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis.
      Title: A Decoy Library Uncovers U-Box E3 Ubiquitin Ligases That Regulate Flowering Time in Arabidopsis.
    3. MAC3A and MAC3B interact with the DCL1 complex that catalyzes miRNA maturation, promote DCL1 activity, and are required for the localization of HYL1, a component of the DCL1 complex.
      Title: MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036394.4
    NM_179875.7
    NM_179876.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of Prp19 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    MOS4-associated complex 3B
    NP_001031471.1
    • MOS4-associated complex 3B (MAC3B); FUNCTIONS IN: ubiquitin-protein ligase activity, nucleotide binding; INVOLVED IN: defense response to bacterium; LOCATED IN: cell wall, CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), U box domain (InterPro:IPR003613), WD40 repeat (InterPro:IPR001680), Pre-mRNA-splicing factor 19 (InterPro:IPR013915), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: MOS4-associated complex 3A (TAIR:AT1G04510.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_850206.4
    • MOS4-associated complex 3B (MAC3B); FUNCTIONS IN: ubiquitin-protein ligase activity, nucleotide binding; INVOLVED IN: defense response to bacterium; LOCATED IN: cell wall, chloroplast, CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), U box domain (InterPro:IPR003613), WD40 repeat (InterPro:IPR001680), Pre-mRNA-splicing factor 19 (InterPro:IPR013915), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: MOS4-associated complex 3A (TAIR:AT1G04510.1); Has 62315 Blast hits to 29584 proteins in 885 species: Archae - 64; Bacteria - 8492; Metazoa - 24454; Fungi - 13690; Plants - 7490; Viruses - 0; Other Eukaryotes - 8125 (source: NCBI BLink).
    NP_850207.4
    • MOS4-associated complex 3B (MAC3B); FUNCTIONS IN: ubiquitin-protein ligase activity, nucleotide binding; INVOLVED IN: defense response to bacterium; LOCATED IN: cell wall, chloroplast, CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), U box domain (InterPro:IPR003613), WD40 repeat (InterPro:IPR001680), Pre-mRNA-splicing factor 19 (InterPro:IPR013915), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: MOS4-associated complex 3A (TAIR:AT1G04510.1); Has 62315 Blast hits to 29584 proteins in 885 species: Archae - 64; Bacteria - 8492; Metazoa - 24454; Fungi - 13690; Plants - 7490; Viruses - 0; Other Eukaryotes - 8125 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14126141..14131224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179875.7 → NP_850206.4  MOS4-associated complex 3B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850206.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1KE07, O22785, Q3EBP5
      UniProtKB/TrEMBL
      A0A178VVW7, A0A5S9X3T9, A0A654EYF2
      Conserved Domains (5) summary
      PRK04863
      Location:90 → 208
      mukB; chromosome partition protein MukB
      cd00200
      Location:224 → 507
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:225 → 262
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:3 → 54
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:67 → 131
      Prp19; Prp19/Pso4-like

    2. NM_179876.5 → NP_850207.4  MOS4-associated complex 3B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850207.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1KE07, O22785, Q3EBP5
      UniProtKB/TrEMBL
      A0A178VVW7, A0A5S9X3T9, A0A654EYF2
      Conserved Domains (5) summary
      PRK04863
      Location:90 → 208
      mukB; chromosome partition protein MukB
      cd00200
      Location:224 → 507
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:225 → 262
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:3 → 54
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:67 → 131
      Prp19; Prp19/Pso4-like

    3. NM_001036394.4 → NP_001031471.1  MOS4-associated complex 3B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VVW7, A0A5S9X3T9, F4IVT2
      Conserved Domains (5) summary
      smart00504
      Location:1 → 65
      Ubox; Modified RING finger domain
      COG2319
      Location:217 → 459
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:224 → 475
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08606
      Location:67 → 130
      Prp19; Prp19/Pso4-like
      sd00039
      Location:225 → 262
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22785.3

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