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    CSN6B COP9 signalosome subunit 6B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828749, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSN6B
    Official Full Name
    COP9 signalosome subunit 6B
    Primary source
    TAIR:AT4G26430
    Locus tag
    AT4G26430
    See related
    Araport:AT4G26430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COP9 signalosome subunit 6B; M3E9.140; M3E9_140
    Summary
    one of two genes encoding subunit 6 of COP9 signalosome complex
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    Genomic context

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    See CSN6B in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (13354992..13357629)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA Neighboring gene WRKY DNA-binding protein 34 Neighboring gene uncharacterized protein Neighboring gene WPP domain interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Peng Z, et al. Plant Cell, 2001 Nov. PMID 11701877, Free PMC Article
    2. Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases. Gusmaroli G, et al. Plant Cell, 2007 Feb. PMID 17307927, Free PMC Article
    3. Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome. Paz-Aviram T, et al. Plant Signal Behav, 2008 Jun. PMID 19704582, Free PMC Article
    4. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
    5. Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. Fu H, et al. EMBO J, 2001 Dec 17. PMID 11742986, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
      Title: Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118776.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome subunit 6B
    NP_567746.1
    • COP9 signalosome subunit 6B (CSN6B); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); BEST Arabidopsis thaliana protein match is: COP9 signalosome subunit 6A (TAIR:AT5G56280.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13354992..13357629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118776.3 → NP_567746.1  COP9 signalosome subunit 6B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65591, Q8RXW5, Q8W1P0, Q8W205
      UniProtKB/TrEMBL
      A0A178V1W2, A0A5S9XY73, A0A7G2F7K0
      Conserved Domains (1) summary
      cd08063
      Location:9 → 310
      MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W1P0.2

    Gene LinkOut

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