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    SLAH2 SLAC1 homologue 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828910, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLAH2
    Official Full Name
    SLAC1 homologue 2
    Primary source
    TAIR:AT4G27970
    Locus tag
    AT4G27970
    See related
    Araport:AT4G27970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SLAC1 homologue 2; T13J8.80; T13J8_80
    Summary
    Encodes a protein with ten predicted transmembrane helices. The SLAH2 protein has similarity to the SLAC1 protein involved in ion homeostasis in guard cells. But, it is not expressed in guard cells and cannot complement a slac1-2 mutant suggesting that it performs a different function. SLAH2:GFP localizes to the plasma membrane.
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    Genomic context

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    See SLAH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (13918165..13920378, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin conjugating enzyme 9 Neighboring gene trichohyalin-like protein (DUF3444) Neighboring gene YGGT family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells. Negi J, et al. Nature, 2008 Mar 27. PMID 18305482
    2. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341891.1
    NM_001341892.1
    NM_001341893.1
    NM_001341894.1
    NM_001341895.1
    NM_118935.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular monoatomic ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SLAC1 homologue 2
    NP_001320078.1
    • SLAC1 homologue 2 (SLAH2); FUNCTIONS IN: transporter activity; INVOLVED IN: transmembrane transport; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 3 (TAIR:AT5G24030.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13918165..13920378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341891.1 → NP_001320078.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ASQ7, Q9SUE2
      UniProtKB/TrEMBL
      A0A178V1C3, A0A5S9XWI7
      Conserved Domains (1) summary
      cd09323
      Location:142 → 445
      TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)

    2. NM_001341892.1 → NP_001328003.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3D9

    3. NM_001341893.1 → NP_001328004.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3E4

    4. NM_118935.3 → NP_567792.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567792.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ASQ7, Q9SUE2
      UniProtKB/TrEMBL
      A0A178V1C3, A0A5S9XWI7
      Conserved Domains (1) summary
      cd09323
      Location:142 → 445
      TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)

    5. NM_001341894.1 → NP_001328005.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3D9

    6. NM_001341895.1 → NP_001328006.1  SLAC1 homologue 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3E4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ASQ7.1

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