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    AMP1 Peptidase M28 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824637, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AMP1
    Official Full Name
    Peptidase M28 family protein
    Primary source
    TAIR:AT3G54720
    Locus tag
    AT3G54720
    See related
    Araport:AT3G54720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALTERED MERISTEM PROGRAM 1; AtAMP1; CONSTITUTIVE MORPHOGENESIS 2; COP2; HAUPTLING; HPT; MFO1; Multifolia; PRIMORDIA TIMING; PT
    Summary
    Encodes glutamate carboxypeptidase. Various alleles show-increased cotyledon number and rate of leaf initiation, show transformation of leaves to cotyledons, altered flowering time and photomorphogenesis and an increased level of cytokinin biosynthesis. Involved in ethylene enhanced hypocotyl elongation in the light. Strong genetic interaction between TGH and AMP1.
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    Genomic context

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    See AMP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (20254639..20257916, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene phosphate transporter 1;7 Neighboring gene CDT1-like protein B Neighboring gene transcription repressor Neighboring gene zein-binding protein (Protein of unknown function, DUF593) Neighboring gene downstream neighbor of Son

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ALTERED MERISTEM PROGRAM1 sustains cellular differentiation by limiting HD-ZIP III transcription factor gene expression. Yang S, et al. Plant Physiol, 2024 Sep 2. PMID 38781290, Free PMC Article
    2. The Arabidopsis AMP1 gene encodes a putative glutamate carboxypeptidase. Helliwell CA, et al. Plant Cell, 2001 Sep. PMID 11549767, Free PMC Article
    3. ALTERED MERISTEM PROGRAM1 regulates leaf identity independently of miR156-mediated translational repression. Fouracre JP, et al. Development, 2020 Apr 27. PMID 32198155, Free PMC Article
    4. ALTERED MERISTEM PROGRAM1 has conflicting effects on the tolerance to heat shock and symptom development after Pseudomonas syringae infection. Lee MW, et al. Biochem Biophys Res Commun, 2016 Nov 18. PMID 27743891
    5. The Small Molecule Hyperphyllin Enhances Leaf Formation Rate and Mimics Shoot Meristem Integrity Defects Associated with AMP1 Deficiency. Poretska O, et al. Plant Physiol, 2016 Jun. PMID 27208298, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum protein ALTERED MERISTEM PROGRAM 1 negatively regulates senescence in Arabidopsis.
      Title: Endoplasmic reticulum protein ALTERED MERISTEM PROGRAM 1 negatively regulates senescence in Arabidopsis.
    2. ALTERED MERISTEM PROGRAM1 sustains cellular differentiation by limiting HD-ZIP III transcription factor gene expression.
      Title: ALTERED MERISTEM PROGRAM1 sustains cellular differentiation by limiting HD-ZIP III transcription factor gene expression.
    3. ALTERED MERISTEM PROGRAM1 regulates leaf identity independently of miR156-mediated translational repression.
      Title: ALTERED MERISTEM PROGRAM1 regulates leaf identity independently of miR156-mediated translational repression.
    4. AMP1 and CYP78A5/7 act through a common pathway to govern cell fate maintenance in Arabidopsis thaliana.
      Title: AMP1 and CYP78A5/7 act through a common pathway to govern cell fate maintenance in Arabidopsis thaliana.
    5. AMP1 role in the shoot meristem proliferation and the regulation of RAP2.6L expression.
      Title: ALTERED MERISTEM PROGRAM1 Restricts Shoot Meristem Proliferation and Regeneration by Limiting HD-ZIP III-Mediated Expression of RAP2.6L.
    6. Hyperphyllin-treated wild-type plants showed amp1-related tissue-specific changes of various marker genes and a significant transcriptomic overlap with the mutant.
      Title: The Small Molecule Hyperphyllin Enhances Leaf Formation Rate and Mimics Shoot Meristem Integrity Defects Associated with AMP1 Deficiency.
    7. Taken together, perturbation of CK- and ABA-related events by AMP1 mutation caused aberrant development phenotype and conflicting responses against abiotic and biotic stresses in Arabidopsis.
      Title: ALTERED MERISTEM PROGRAM1 has conflicting effects on the tolerance to heat shock and symptom development after Pseudomonas syringae infection.
    8. De novo formation of supernumerary stem cell pools was enhanced in plants mutated in both AMP1 and its paralog LIKE AMP1, indicating that they exhibit partially overlapping roles to suppress stem cell niches respecification in the peripheral zone.
      Title: ALTERED MERISTEM PROGRAM1 suppresses ectopic stem cell niche formation in the shoot apical meristem in a largely cytokinin-independent manner.
    9. Loss of ALTERED MERISTEM PROGRAM 1 function leads to supernumerary egg cells at the expense of synergids, enabling the generation of dizygotic twins. If twin embryos are formed, endosperm formation is prevented, eventually resulting in ovule abortion.
      Title: Twin plants from supernumerary egg cells in Arabidopsis.
    10. AMP1 mediates abscisic acid, oxidative and abiotic stress responses and is involved in carbon and amino acid metabolism in Arabidopsis.
      Title: The glutamate carboxypeptidase AMP1 mediates abscisic acid and abiotic stress responses in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    • At3g54720_Arabidopsis_lyrata_ssp._lyrata_CAN1 (e-PCR)
    • At3g54720_Arabidopsis_lyrata_ssp._petraea_GER1 (e-PCR)
    NM_115329.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M28 family protein
    NP_567007.1
    • ALTERED MERISTEM PROGRAM 1 (AMP1); CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Transferrin receptor-like, dimerisation (InterPro:IPR007365), Peptidase M28 (InterPro:IPR007484); BEST Arabidopsis thaliana protein match is: Peptidase M28 family protein (TAIR:AT5G19740.1); Has 3363 Blast hits to 3338 proteins in 594 species: Archae - 10; Bacteria - 1310; Metazoa - 699; Fungi - 446; Plants - 316; Viruses - 0; Other Eukaryotes - 582 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20254639..20257916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115329.3 → NP_567007.1  Peptidase M28 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567007.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5X581, Q9M1S8
      UniProtKB/TrEMBL
      A0A178VCM8, A0A5S9XL16
      Conserved Domains (3) summary
      cd08022
      Location:332 → 556
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:585 → 701
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl10459
      Location:141 → 321
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1S8.3

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