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    MIS12 minichromosome instability 12 (mis12)-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833516, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIS12
    Official Full Name
    minichromosome instability 12 (mis12)-like protein
    Primary source
    TAIR:AT5G35520
    Locus tag
    AT5G35520
    See related
    Araport:AT5G35520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MINICHROMOSOME INSTABILITY 12 (MIS12)-LIKE; ATMIS12; MINICHROMOSOME INSTABILITY 12 (MIS12)-LIKE; MINICHROMOSOME INSTABILITY 12 HOMOLOGUE; MIS12 HOMOLOGUE; MOK9.12; MOK9_12
    Summary
    encodes a homologue of the yeast (S. pombe) Mis12 (minichromosome instability) protein. MIS12 co-localizes with 180 bp repeats of centromeric DNA throughout the cell cycle with a similar pattern to AtCENH3/HTR12. Neither of these two proteins completely cover the 180 bp regions based on FISH analysis.
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    Genomic context

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    See MIS12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (13701290..13703241)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene TIR-NBS-LRR class disease resistance protein Neighboring gene PLAC8 family protein Neighboring gene Ribosomal protein S3 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Mis12 homologue in Arabidopsis thaliana. Sato H, et al. Chromosome Res, 2005. PMID 16331414
    2. Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana. Ravi M, et al. PLoS Genet, 2011 Jun. PMID 21695238, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_122943.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    minichromosome instability 12 (mis12)-like protein
    NP_198402.2
    • MINICHROMOSOME INSTABILITY 12 (MIS12)-LIKE (MIS12); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: mitosis, cell cycle; LOCATED IN: chromosome, centromeric region, nucleus; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Centromere protein Mis12 (InterPro:IPR008685); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      13701290..13703241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122943.3 → NP_198402.2  minichromosome instability 12 (mis12)-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198402.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V0Z5, Q9FJA7
      UniProtKB/TrEMBL
      A0A178UCY0, A0A5S9Y893
      Conserved Domains (1) summary
      pfam05859
      Location:9 → 139
      Mis12; Mis12 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2V0Z5.1

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