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    RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834160, updated on 18-Sep-2024

    Summary

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    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT5G41580
    Locus tag
    AT5G41580
    See related
    Araport:AT5G41580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MBK23.10; MBK23_10; PIAL2; PROTEIN INHIBITOR OF ACTIVATED STAT LIKE 2
    Summary
    Encodes an SP-RING domain containing protein that functions in sumolaytion and is involved in positive regulation of sulfur metabolism and stress response.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (16626185..16630820, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DET1 complexing ubiquitin ligase Neighboring gene WRKY DNA-binding protein 24 Neighboring gene LURP-one-like protein (DUF567) Neighboring gene VIRB2-interacting protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism. Tomanov K, et al. Plant Cell, 2014 Nov. PMID 25415977, Free PMC Article
    2. Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing. Zhao QY, et al. PLoS One, 2018. PMID 30092097, Free PMC Article
    3. The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing. Han YF, et al. Plant Cell, 2016 May. PMID 27113777, Free PMC Article
    4. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the conserved PIAL2 interaction domain is exclusively responsible for the interaction of PIAL2 with MOM1
      Title: Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.
    2. study suggests that PIAL1 and PIAl2 act as components of the MOM1-containing complex to mediate transcriptional silencing at heterochromatin regions.
      Title: The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.
    3. PIAL1 and PIAL2 function as small ubiquitin-related modifier (SUMO) ligases capable of SUMO chain formation and require the SUMO-modified SUMO-conjugating enzyme SCE1 for optimal activity.
      Title: Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123522.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables SUMO transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of sulfur metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene silencing by regulatory ncRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_198973.3
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, MIZ-type (InterPro:IPR004181); BEST Arabidopsis thaliana protein match is: zinc ion binding;zinc ion binding (TAIR:AT1G08910.1); Has 2409 Blast hits to 1813 proteins in 283 species: Archae - 4; Bacteria - 96; Metazoa - 1110; Fungi - 536; Plants - 146; Viruses - 31; Other Eukaryotes - 486 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16626185..16630820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123522.4 → NP_198973.3  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198973.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JYG0, Q0WP46, Q9FFS2
      UniProtKB/TrEMBL
      A0A178UER0, A0A178UGV0, A0A5S9YCC4
      Conserved Domains (2) summary
      pfam05109
      Location:531 → 758
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16650
      Location:310 → 357
      SP-RING_PIAS_like; SP-RING finger found in the Siz/PIAS RING (SP-RING) family of SUMO E3 ligases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JYG0.1

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