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    WD-40 repeat family protein / notchless protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835359, updated on 18-Sep-2024

    Summary

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    Official Full Name
    WD-40 repeat family protein / notchless protein
    Primary source
    TAIR:AT5G52820
    Locus tag
    AT5G52820
    See related
    Araport:AT5G52820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNLE; MXC20.4; MXC20_4; NLE; NOTCHLESS
    Summary
    Encodes a NOTCHLESS homolog, a non-ribosomal protein involved in the maturation and assembly of the 60S ribosomal subunit, that is required for female gametogenesis.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (21401312..21404470)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DNA primase Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene tRNA-Lys Neighboring gene WRKY DNA-binding protein 27 Neighboring gene NADH-ubiquinone oxidoreductase-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis NOTCHLESS plays an important role in root and embryo development. Li K, et al. Plant Signal Behav, 2023 Dec 31. PMID 37573563, Free PMC Article
    2. The MIDASIN and NOTCHLESS genes are essential for female gametophyte development in Arabidopsis thaliana. Chantha SC, et al. Physiol Mol Biol Plants, 2010 Jan. PMID 23572950, Free PMC Article
    3. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    4. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis NOTCHLESS plays an important role in root and embryo development.
      Title: Arabidopsis NOTCHLESS plays an important role in root and embryo development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_124660.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ribosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WD-40 repeat family protein / notchless protein
    NP_200094.1
    • WD-40 repeat family protein / notchless protein, putative; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), NLE (InterPro:IPR012972), WD40 repeat (InterPro:IPR001680), G-protein, beta subunit (InterPro:IPR001632), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT3G49660.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21401312..21404470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124660.4 → NP_200094.1  WD-40 repeat family protein / notchless protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLX9
      UniProtKB/TrEMBL
      A0A178UNZ3, A0A5S9YE52, A0A7G2FGE6
      Conserved Domains (4) summary
      smart00320
      Location:433 → 472
      WD40; WD40 repeats
      cd00200
      Location:101 → 430
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:154 → 192
      7WD40; WD40 repeat [structural motif]
      pfam08154
      Location:12 → 72
      NLE; NLE (NUC135) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLX9.1

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